PGS Publication: PGP000602

Publication Information (EuropePMC)
Title Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.
PubMed ID 38380516(Europe PMC)
doi 10.1161/circgen.123.004272
Publication Date Feb. 21, 2024
Journal Circ Genom Precis Med
Author(s) Smith JL, Tcheandjieu C, Dikilitas O, Iyer K, Miyazawa K, Hilliard A, Lynch J, Rotter JI, Chen YI, Sheu WH, Chang KM, Kanoni S, Tsao P, Ito K, Kosel M, Clarke SL, Schaid DJ, Assimes TL, Kullo IJ.
Released in PGS Catalog: March 18, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004697
(eur_anc_hg37CSx)
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Coronary heart disease coronary artery disease 1,120,251
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004697/ScoringFiles/PGS004697.txt.gz
PGS004696
(multi_anc_hg37CSx)
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Coronary heart disease coronary artery disease 1,289,980
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004696/ScoringFiles/PGS004696.txt.gz
PGS004698
(multi_anc_hg37PT)
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Coronary heart disease coronary artery disease 542,218
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004698/ScoringFiles/PGS004698.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020903 PGS004697
(eur_anc_hg37CSx)
 PSS011448|
European Ancestry|
52,702 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.55 [1.5, 1.6] AUROC: 0.773 — age, sex, 10 PCs —
PPM020904 PGS004696
(multi_anc_hg37CSx)
 PSS011448|
European Ancestry|
52,702 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.65 [1.59, 1.71] AUROC: 0.774 — age, sex, 10 PCs —
PPM020905 PGS004697
(eur_anc_hg37CSx)
 PSS011446|
African Ancestry|
17,008 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.25 [1.17, 1.33] AUROC: 0.734 — age, sex, 10 PCs —
PPM020906 PGS004696
(multi_anc_hg37CSx)
 PSS011446|
African Ancestry|
17,008 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.2 [1.15, 1.26] AUROC: 0.736 — age, sex, 10 PCs —
PPM020907 PGS004697
(eur_anc_hg37CSx)
 PSS011449|
Hispanic or Latin American Ancestry|
6,138 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.52 [1.36, 1.71] AUROC: 0.708 — age, sex, 10 PCs —
PPM020908 PGS004696
(multi_anc_hg37CSx)
 PSS011449|
Hispanic or Latin American Ancestry|
6,138 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.51 [1.35, 1.69] AUROC: 0.706 — age, sex, 10 PCs —
PPM020909 PGS004697
(eur_anc_hg37CSx)
 PSS011447|
East Asian Ancestry|
22,751 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.51 [1.44, 1.59] AUROC: 0.756 — age, sex, 10 PCs —
PPM020910 PGS004696
(multi_anc_hg37CSx)
 PSS011447|
East Asian Ancestry|
22,751 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.59 [1.54, 1.64] AUROC: 0.762 — age, sex, 10 PCs —
PPM020911 PGS004697
(eur_anc_hg37CSx)
 PSS011450|
South Asian Ancestry|
9,178 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 2.47 [2.23, 2.73] AUROC: 0.803 — age, sex, 10 PCs —
PPM020912 PGS004696
(multi_anc_hg37CSx)
 PSS011450|
South Asian Ancestry|
9,178 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 2.67 [2.39, 3.01] AUROC: 0.803 — age, sex, 10 PCs —
PPM020913 PGS004698
(multi_anc_hg37PT)
 PSS011448|
European Ancestry|
52,702 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.65 [1.59 -1.72) AUROC: 0.773 — age, sex, 10 PCs —
PPM020914 PGS004698
(multi_anc_hg37PT)
 PSS011446|
African Ancestry|
17,008 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.16 [1.11, 1.21] AUROC: 0.735 — age, sex, 10 PCs —
PPM020915 PGS004698
(multi_anc_hg37PT)
 PSS011449|
Hispanic or Latin American Ancestry|
6,138 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.38 [1.24, 1.54] AUROC: 0.699 — age, sex, 10 PCs —
PPM020916 PGS004698
(multi_anc_hg37PT)
 PSS011447|
East Asian Ancestry|
22,751 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 1.56 [1.5, 1.61] AUROC: 0.748 — age, sex, 10 PCs —
PPM020917 PGS004698
(multi_anc_hg37PT)
 PSS011450|
South Asian Ancestry|
9,178 individuals
 PGP000602 |
Smith JL et al. Circ Genom Precis Med (2024)
 Reported Trait: Incident coronary heart disease OR: 2.75 [2.41, 3.14] AUROC: 0.786 — age, sex, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011446 — —
[
  • 1,359 cases
  • , 15,649 controls
]
 — African unspecified — ARIC, CHS, MESA, WHI, eMERGE —
PSS011447 — —
[
  • 6,321 cases
  • , 16,430 controls
]
 — East Asian — BBJ, OACIS, TaiChi —
PSS011448 — —
[
  • 4,970 cases
  • , 47,732 controls
]
 — European — ARIC, CHS, MESA, WHI, eMERGE —
PSS011449 — —
[
  • 314 cases
  • , 5,824 controls
]
 — Hispanic or Latin American — MESA, WHI, eMERGE —
PSS011450 — —
[
  • 517 cases
  • , 8,661 controls
]
 — South Asian — UKB —