Polygenic Score (PGS) ID: PGS003761

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: Aug. 4, 2023
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Score Details

Score Construction
PGS Name PRS165_AF
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 165
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000484
Citation (link to publication) Zhang J et al. BMC Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,030,836 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006414
Europe PMC: 30061737
 1,030,836 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018558 PSS011022|
Multi-ancestry (including European)|
84,206 individuals
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden — — Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 7.32 [3.02, 17.7] sex —
PPM018559 PSS011023|
Multi-ancestry (including European)|
117,520 individuals
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden — — Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 8.41 [4.37, 16.2] sex —
PPM018560 PSS011024|
Multi-ancestry (including European)|
147,178 individuals
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden — — Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 4.12 [2.76, 6.14] sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011023 — — 6,783 individuals Not reported — UKB —
PSS011024 — — 142,614 individuals European — UKB —
PSS011024 — — 4,564 individuals Not reported — UKB —
PSS011022 — — 75,886 individuals European — UKB —
PSS011022 — — 8,320 individuals Not reported — UKB —
PSS011023 — — 110,737 individuals European — UKB —