PGS Publication: PGP000484

Publication Information (EuropePMC)
Title Associations of risk factor burden and genetic predisposition with the 10-year risk of atrial fibrillation: observations from a large prospective study of 348,904 participants.
PubMed ID 36882748(Europe PMC)
doi 10.1186/s12916-023-02798-7
Publication Date March 8, 2023
Journal BMC Med
Author(s) Zhang J, Chen G, Wang C, Wang X, Qian ZM, Cai M, Vaughn MG, Bingheim E, Li H, Gao Y, Lip GYH, Lin H.
Released in PGS Catalog: Aug. 4, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003761
(PRS165_AF)
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Atrial fibrillation atrial fibrillation 165
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003761/ScoringFiles/PGS003761.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018558 PGS003761
(PRS165_AF)
 PSS011022|
Multi-ancestry (including European)|
84,206 individuals
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden — — Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 7.32 [3.02, 17.7] sex —
PPM018559 PGS003761
(PRS165_AF)
 PSS011023|
Multi-ancestry (including European)|
117,520 individuals
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden — — Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 8.41 [4.37, 16.2] sex —
PPM018560 PGS003761
(PRS165_AF)
 PSS011024|
Multi-ancestry (including European)|
147,178 individuals
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden — — Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 4.12 [2.76, 6.14] sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011023 — — 6,783 individuals Not reported — UKB —
PSS011024 — — 142,614 individuals European — UKB —
PSS011024 — — 4,564 individuals Not reported — UKB —
PSS011022 — — 75,886 individuals European — UKB —
PSS011022 — — 8,320 individuals Not reported — UKB —
PSS011023 — — 110,737 individuals European — UKB —