PGS Publication: PGP000017

Publication Information (EuropePMC)
Title Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.
PubMed ID 31002795(Europe PMC)
doi 10.1016/j.cell.2019.03.028
Publication Date April 1, 2019
Journal Cell
Author(s) Khera AV, Chaffin M, Wade KH, Zahid S, Brancale J, Xia R, Distefano M, Senol-Cosar O, Haas ME, Bick ... A, Aragam KG, Lander ES, Smith GD, Mason-Suares H, Fornage M, Lebo M, Timpson NJ, Kaplan LM, Kathiresan S.Show more
Released in PGS Catalog: Oct. 14, 2019

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000027
(GPS_BMI)
PGP000017 |
Khera AV et al. Cell (2019)
Body mass index (BMI)body mass index2,100,302
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000027/ScoringFiles/PGS000027.txt.gz - Check Terms/Licenses
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM000054PGS000027
(GPS_BMI)
PSS000037|
European Ancestry|
288,016 individuals
PGP000017 |
Khera AV et al. Cell (2019)
Reported Trait: Body mass indexβ: 1.41—R²: 0.08526First 10 genetic PCsBeta is in units of kg/m^2
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000037——288,016 individuals,
45.0 % Male samples
—European—UKB—
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