PGS Publication: PGP000017

Publication Information (EuropePMC)
Title Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.
PubMed ID 31002795(Europe PMC)
doi 10.1016/j.cell.2019.03.028
Publication Date April 1, 2019
Journal Cell
Author(s) Khera AV, Chaffin M, Wade KH, Zahid S, Brancale J, Xia R, Distefano M, Senol-Cosar O, Haas ME, Bick A, Aragam KG, Lander ES, Smith GD, Mason-Suares H, Fornage M, Lebo M, Timpson NJ, Kaplan LM, Kathiresan S.
Released in PGS Catalog: Oct. 14, 2019

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000027
(GPS_BMI)
 PGP000017 |
Khera AV et al. Cell (2019)
 Body mass index (BMI) body mass index 2,100,302
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000027/ScoringFiles/PGS000027.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000054 PGS000027
(GPS_BMI)
 PSS000037|
European Ancestry|
288,016 individuals
 PGP000017 |
Khera AV et al. Cell (2019)
 Reported Trait: Body mass index β: 1.41 — R²: 0.08526 First 10 genetic PCs Beta is in units of kg/m^2

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000037 — — 288,016 individuals,
45.0 % Male samples
 — European — UKB —