PGS Publication: PGP000031

Publication Information (EuropePMC)
Title Reducing overdiagnosis by polygenic risk-stratified screening: findings from the Finnish section of the ERSPC.
PubMed ID 26291059(Europe PMC)
doi 10.1038/bjc.2015.289
Publication Date Aug. 20, 2015
Journal Br J Cancer
Author(s) Pashayan N, Pharoah PD, Schleutker J, Talala K, Tammela TLj, Määttänen L, Harrington P, Tyrer J, Eeles R, Duffy SW, Auvinen A.
Released in PGS Catalog: Dec. 18, 2019

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000044
(PrCa66)
 PGP000031 |
Pashayan N et al. Br J Cancer (2015)
 Prostate cancer prostate carcinoma 66
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000044/ScoringFiles/PGS000044.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000104 PGS000044
(PrCa66)
 PSS000068|
European Ancestry|
17,012 individuals
 PGP000031 |
Pashayan N et al. Br J Cancer (2015)
 Reported Trait: Elevated serum prostate-specific antigen (PSA) levels — — OR (per 1-point increase in PRS): 1.23 [1.1, 1.37] cancer stage, Gleason score —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000068 Prostate cancer was classified as localized disease with tumor-node-metastasis stage T2 and below and advanced disease (regional-distant) was classified as localized disease with tumor-node-metastasis stage T3 and above (low aggressive tumor, Gleason score <7; intermediate to highly aggressive tumor, Gleason score ≥7). Elevated serum prostate-specific antigen (PSA) levels were defined as ≥4 ng/ml. —
[
  • 3,157 cases
  • , 0 controls
]
,
100.0 % Male samples
 Range = [50.0, 60.0] years European — UKGPCS —
PSS000068 Prostate cancer was classified as localized disease with tumor-node-metastasis stage T2 and below and advanced disease (regional-distant) was classified as localized disease with tumor-node-metastasis stage T3 and above (low aggressive tumor, Gleason score <7; intermediate to highly aggressive tumor, Gleason score ≥7). Elevated serum prostate-specific antigen (PSA) levels were defined as ≥4 ng/ml. —
[
  • 2,148 cases
  • , 6,648 controls
]
,
100.0 % Male samples
 Range = [50.0, 69.0] years European — ProtecT —
PSS000068 Prostate cancer was classified as localized disease with tumor-node-metastasis stage T2 and below and advanced disease (regional-distant) was classified as localized disease with tumor-node-metastasis stage T3 and above (low aggressive tumor, Gleason score <7; intermediate to highly aggressive tumor, Gleason score ≥7). Elevated serum prostate-specific antigen (PSA) levels were defined as ≥4 ng/ml. —
[
  • 4,099 cases
  • , 960 controls
]
,
100.0 % Male samples
 Range = [50.0, 69.0] years European — SEARCH —