PGS Publication: PGP000044

Publication Information (EuropePMC)
Title Coronary Heart Disease Genetic Risk Score Predicts Cardiovascular Disease Risk in Men, Not Women.
PubMed ID 30354305(Europe PMC)
doi 10.1161/CIRCGEN.118.002324
Publication Date Oct. 1, 2018
Journal Circ Genom Precis Med
Author(s) Hajek C, Guo X, Yao J, Hai Y, Johnson WC, Frazier-Wood AC, Post WS, Psaty BM, Taylor KD, Rotter JI.
Released in PGS Catalog: Dec. 18, 2019

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000059
(CHD46)
 PGP000044 |
Hajek C et al. Circ Genom Precis Med (2018)
 Coronary heart disease coronary artery disease 46
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000059/ScoringFiles/PGS000059.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000150 PGS000059
(CHD46)
 PSS000094|
European Ancestry|
1,320 individuals
 PGP000044 |
Hajek C et al. Circ Genom Precis Med (2018)
 Reported Trait: Incident coronary heart disease — — HR (top vs. bottom quartiles of GRS): 0.76 [0.41, 1.39]
p-value (association between risk and incidence): 0.31		 NR —
PPM000149 PGS000059
(CHD46)
 PSS000095|
European Ancestry|
1,206 individuals
 PGP000044 |
Hajek C et al. Circ Genom Precis Med (2018)
 Reported Trait: Incident coronary heart disease — — HR (top vs. bottom quartiles of GRS): 1.92 [1.19, 3.11]
p-value (association between risk and incidence): 0.029		 NR —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000094 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death —
[
  • 86 cases
  • , 1,234 controls
]
 Mean = 62.6 years European Analysis restricted to "White participants" MESA —
PSS000095 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death —
[
  • 144 cases
  • , 1,062 controls
]
 Mean = 62.7 years European Analysis restricted to "White participants" MESA —