PGS Publication: PGP000070

Publication Information (EuropePMC)
Title Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study.
PubMed ID 28233817(Europe PMC)
doi 10.1038/srep43263
Publication Date Feb. 24, 2017
Journal Sci Rep
Author(s) Ibáñez-Sanz G, Ibáñez-Sanz G, Díez-Villanueva A, Alonso MH, Rodríguez-Moranta F, Pérez-Gómez B, Bustamante M, Martin V, Llorca J, Amiano P, Ardanaz E, Tardón A, Jiménez-Moleón JJ, Peiró R, Alguacil J, Navarro C, Guinó E, Binefa G, Fernández-Navarro P, Espinosa A, Dávila-Batista V, Molina AJ, Palazuelos C, Castaño-Vinyals G, Aragonés N, Kogevinas M, Pollán M, Moreno V.
Released in PGS Catalog: April 29, 2020

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000147
(CRC21)
 PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
 Colorectal cancer colorectal cancer 21
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000147/ScoringFiles/PGS000147.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000448 PGS000147
(CRC21)
 PSS000259|
European Ancestry|
4,080 individuals
 PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
 Reported Trait: Colorectal cancer — AUROC: 0.63 [0.6, 0.66] Odds Ratio (OR; per allele): 1.07 [1.04, 1.1] environmental risk factors ( alcohol consumption, obesity, physical activity, red meat and vegetable consumption, nonsteroidal anti-inflammatory drug use), family history —
PPM000447 PGS000147
(CRC21)
 PSS000259|
European Ancestry|
4,080 individuals
 PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
 Reported Trait: Rectal cancer — — Odds Ratio (OR; per allele): 1.1 [1.06, 1.15] environmental risk factors ( alcohol consumption, obesity, physical activity, red meat and vegetable consumption, nonsteroidal anti-inflammatory drug use), family history —
PPM000446 PGS000147
(CRC21)
 PSS000259|
European Ancestry|
4,080 individuals
 PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
 Reported Trait: Colon cancer — — Odds Ratio (OR; per allele): 1.06 [1.03, 1.09] environmental risk factors ( alcohol consumption, obesity, physical activity, red meat and vegetable consumption, nonsteroidal anti-inflammatory drug use), family history —
PPM000449 PGS000147
(CRC21)
 PSS000259|
European Ancestry|
4,080 individuals
 PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
 Reported Trait: Colorectal cancer — AUROC: 0.56 [0.54, 0.58] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000259 — —
[
  • 1,336 cases
  • , 2,744 controls
]
,
57.21 % Male samples
 Range = [25.0, 90.0] years European
(Spanish)		 — MCC-Spain —