PGS Publication: PGP000079

Publication Information (EuropePMC)
Title Polymorphisms associated with cholesterol and risk of cardiovascular events.
PubMed ID 18354102(Europe PMC)
doi 10.1056/nejmoa0706728
Publication Date March 1, 2008
Journal N Engl J Med
Author(s) Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt NP, Roos C, Hirschhorn JN, Berglund G, Hedblad B, Groop L, Altshuler DM, Newton-Cheh C, Orho-Melander M.
Released in PGS Catalog: May 20, 2020

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000192
(GS9)
 PGP000079 |
Kathiresan S et al. N Engl J Med (2008)
 Cholesterol low density lipoprotein cholesterol measurement,
high density lipoprotein cholesterol measurement		 9
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000192/ScoringFiles/PGS000192.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000563 PGS000192
(GS9)
 PSS000292|
European Ancestry|
4,232 individuals
 PGP000079 |
Kathiresan S et al. N Engl J Med (2008)
 Reported Trait: Incident cardiovascular event — AUROC: 0.8 Hazard Ratio (HR; per allele): 1.15 [1.07, 1.24] age, sex, family history of MI, LDL cholesterol, HDL cholesterol, triglycerides, blood pressure, body mass index, diabetes status, smoking status, CRP, lipid lowering medication —
PPM000562 PGS000192
(GS9)
 PSS000292|
European Ancestry|
4,232 individuals
 PGP000079 |
Kathiresan S et al. N Engl J Med (2008)
 Reported Trait: High-density lipoprotein (HDL) levels — — Association p-value: 2.00e-18 — —
PPM000561 PGS000192
(GS9)
 PSS000292|
European Ancestry|
4,232 individuals
 PGP000079 |
Kathiresan S et al. N Engl J Med (2008)
 Reported Trait: Low-density lipoprotein (LDL) levels — — Association p-value: 3.00e-24 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000292 Composite end point of cardiovascular events was defined as myocardial infarction, ischemic stroke, and death from coronary heart disease. Death from coronary heart disease was defined on the basis of codes 412 and 414 (ICD-9) or I22–I23 and I25 (ICD-10) in the Swedish Cause of Death Register. Myocardial infarction was defined on the basis of codes 410 and I21 in the International Classification of Diseases, 9th Revision and 10th Revision (ICD-9 and ICD-10), respectively. Ischemic stroke was defined on the basis of codes 434 or 436 (ICD-9) and I63 or I64 (ICD-10). Median = 10.6 years
[
  • 238 cases
  • , 3,994 controls
]
 — European — MDC —