PGS Publication: PGP000082

Publication Information (EuropePMC)
Title Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease.
PubMed ID 23599444(Europe PMC)
doi 10.1161/atvbaha.112.301120
Publication Date April 18, 2013
Journal Arterioscler Thromb Vasc Biol
Author(s) Tikkanen E, Havulinna AS, Palotie A, Salomaa V, Ripatti S.
Released in PGS Catalog: June 3, 2020

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000200
(GRS28)
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Coronary heart disease coronary artery disease 28
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000200/ScoringFiles/PGS000200.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000583 PGS000200
(GRS28)
 PSS000330|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident cardiovascular disease HR: 1.18 [1.12, 1.24] — — sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000585 PGS000200
(GRS28)
 PSS000328|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident acute coronary syndrome HR: 1.27 [1.18, 1.37] — — sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000584 PGS000200
(GRS28)
 PSS000329|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident coronary heart disease HR: 1.27 [1.2, 1.35] — — sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000588 PGS000200
(GRS28)
 PSS000328|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident acute coronary syndrome — C-index: 0.859 ΔC-index (over covariate only model): 0.004 [0.003, 0.005] sex, total cholesterol, high-density lipoprotein-cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000587 PGS000200
(GRS28)
 PSS000329|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident coronary heart disease — C-index: 0.856 ΔC-index (over covariate only model): 0.005 [0.004, 0.006] sex, total cholesterol, high-density lipoprotein-cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000586 PGS000200
(GRS28)
 PSS000330|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident cardiovascular disease — C-index: 0.84 ΔC-index (over covariate only model): 0.003 [0.002, 0.004] sex, total cholesterol, high-density lipoprotein-cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 19.0 years
[
  • 235 cases
  • , 4,869 controls
]
,
44.8 % Male samples
 Mean = 43.9 years
Sd = 11.3 years		 European
(Finnish)		 — FINRISK FINRISK 1992
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 14.0 years
[
  • 229 cases
  • , 6,338 controls
]
,
45.8 % Male samples
 Mean = 46.8 years
Sd = 12.9 years		 European
(Finnish)		 — FINRISK97 FINRISK 1997
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 9.0 years
[
  • 148 cases
  • , 7,182 controls
]
,
45.0 % Male samples
 Mean = 47.5 years
Sd = 13.0 years		 European
(Finnish)		 — FINRISK FINRISK 2002
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 8.0 years
[
  • 119 cases
  • , 5,004 controls
]
,
46.3 % Male samples
 Mean = 50.0 years
Sd = 11.7 years		 European
(Finnish)		 — Health2000 —
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 19.0 years
[
  • 343 cases
  • , 4,761 controls
]
,
44.8 % Male samples
 Mean = 43.9 years
Sd = 11.3 years		 European
(Finnish)		 — FINRISK FINRISK 1992
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 14.0 years
[
  • 344 cases
  • , 6,223 controls
]
,
45.8 % Male samples
 Mean = 46.8 years
Sd = 12.9 years		 European
(Finnish)		 — FINRISK97 FINRISK 1997
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 9.0 years
[
  • 209 cases
  • , 7,121 controls
]
,
45.0 % Male samples
 Mean = 47.5 years
Sd = 13.0 years		 European
(Finnish)		 — FINRISK FINRISK 2002
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 8.0 years
[
  • 197 cases
  • , 4,926 controls
]
,
46.3 % Male samples
 Mean = 50.0 years
Sd = 11.7 years		 European
(Finnish)		 — Health2000 —
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 19.0 years
[
  • 501 cases
  • , 4,603 controls
]
,
44.8 % Male samples
 Mean = 43.9 years
Sd = 11.3 years		 European
(Finnish)		 — FINRISK FINRISK 1992
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 14.0 years
[
  • 499 cases
  • , 6,068 controls
]
,
45.8 % Male samples
 Mean = 46.8 years
Sd = 12.9 years		 European
(Finnish)		 — FINRISK97 FINRISK 1997
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 9.0 years
[
  • 291 cases
  • , 7,039 controls
]
,
45.0 % Male samples
 Mean = 47.5 years
Sd = 13.0 years		 European
(Finnish)		 — FINRISK FINRISK 2002
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 8.0 years
[
  • 261 cases
  • , 4,862 controls
]
,
46.3 % Male samples
 Mean = 50.0 years
Sd = 11.7 years		 European
(Finnish)		 — Health2000 —