PGS Publication: PGP000082

Publication Information (EuropePMC)
Title Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease.
PubMed ID 23599444(Europe PMC)
doi 10.1161/atvbaha.112.301120
Publication Date April 18, 2013
Journal Arterioscler Thromb Vasc Biol
Author(s) Tikkanen E, Havulinna AS, Palotie A, Salomaa V, Ripatti S.
Released in PGS Catalog: June 3, 2020

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000200
(GRS28)
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Coronary heart diseasecoronary artery disease28
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000200/ScoringFiles/PGS000200.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM000583PGS000200
(GRS28)
PSS000330|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident cardiovascular diseaseHR: 1.18 [1.12, 1.24]——sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressu... re, antihypertensive treatment, smoking, type 2 diabetes mellitusShow moreAge as timescale Cox regression
PPM000584PGS000200
(GRS28)
PSS000329|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident coronary heart diseaseHR: 1.27 [1.2, 1.35]——sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressu... re, antihypertensive treatment, smoking, type 2 diabetes mellitusShow moreAge as timescale Cox regression
PPM000585PGS000200
(GRS28)
PSS000328|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident acute coronary syndromeHR: 1.27 [1.18, 1.37]——sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressu... re, antihypertensive treatment, smoking, type 2 diabetes mellitusShow moreAge as timescale Cox regression
PPM000586PGS000200
(GRS28)
PSS000330|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident cardiovascular disease—C-index: 0.84ΔC-index (over covariate only model): 0.003 [0.002, 0.004]sex, total cholesterol, high-density lipoprotein-cholesterol, body mass index, systolic blood pressu... re, antihypertensive treatment, smoking, type 2 diabetes mellitus, family historyShow moreAge as timescale Cox regression
PPM000587PGS000200
(GRS28)
PSS000329|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident coronary heart disease—C-index: 0.856ΔC-index (over covariate only model): 0.005 [0.004, 0.006]sex, total cholesterol, high-density lipoprotein-cholesterol, body mass index, systolic blood pressu... re, antihypertensive treatment, smoking, type 2 diabetes mellitus, family historyShow moreAge as timescale Cox regression
PPM000588PGS000200
(GRS28)
PSS000328|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident acute coronary syndrome—C-index: 0.859ΔC-index (over covariate only model): 0.004 [0.003, 0.005]sex, total cholesterol, high-density lipoprotein-cholesterol, body mass index, systolic blood pressu... re, antihypertensive treatment, smoking, type 2 diabetes mellitus, family historyShow moreAge as timescale Cox regression
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000328ACS was defined as MI, unstable angina or death due to CHD.Mean = 19.0 years
[
  • 235 cases
  • , 4,869 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years		European
(Finnish)		—FINRISKFINRISK 1992
PSS000328ACS was defined as MI, unstable angina or death due to CHD.Mean = 14.0 years
[
  • 229 cases
  • , 6,338 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years		European
(Finnish)		—FINRISK97FINRISK 1997
PSS000328ACS was defined as MI, unstable angina or death due to CHD.Mean = 9.0 years
[
  • 148 cases
  • , 7,182 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years		European
(Finnish)		—FINRISKFINRISK 2002
PSS000328ACS was defined as MI, unstable angina or death due to CHD.Mean = 8.0 years
[
  • 119 cases
  • , 5,004 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years		European
(Finnish)		—Health2000—
PSS000329CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coro... nary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD.Show moreMean = 19.0 years
[
  • 343 cases
  • , 4,761 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years		European
(Finnish)		—FINRISKFINRISK 1992
PSS000329CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coro... nary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD.Show moreMean = 14.0 years
[
  • 344 cases
  • , 6,223 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years		European
(Finnish)		—FINRISK97FINRISK 1997
PSS000329CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coro... nary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD.Show moreMean = 9.0 years
[
  • 209 cases
  • , 7,121 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years		European
(Finnish)		—FINRISKFINRISK 2002
PSS000329CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coro... nary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD.Show moreMean = 8.0 years
[
  • 197 cases
  • , 4,926 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years		European
(Finnish)		—Health2000—
PSS000330CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coro... nary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events.Show moreMean = 19.0 years
[
  • 501 cases
  • , 4,603 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years		European
(Finnish)		—FINRISKFINRISK 1992
PSS000330CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coro... nary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events.Show moreMean = 14.0 years
[
  • 499 cases
  • , 6,068 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years		European
(Finnish)		—FINRISK97FINRISK 1997
PSS000330CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coro... nary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events.Show moreMean = 9.0 years
[
  • 291 cases
  • , 7,039 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years		European
(Finnish)		—FINRISKFINRISK 2002
PSS000330CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coro... nary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events.Show moreMean = 8.0 years
[
  • 261 cases
  • , 4,862 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years		European
(Finnish)		—Health2000—
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