| Publication Information (EuropePMC) | |
| Title | Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals. |
| PubMed ID | 33067605(Europe PMC) |
| doi | 10.1038/s42255-020-00287-2 |
| Publication Date | Oct. 16, 2020 |
| Journal | Nat Metab |
| Author(s) | Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV, Wu Y, Peters J, Eriksson N, Bergen SE, Boutin TS, Bretherick AD, Enroth S, Kalnapenkis A, Gådin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Davey Smith G, de Masi F, Elmståhl S, Engström G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson Å, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Mägi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Pålsson E, Qi T, Sjögren M, Sundström J, Surendran P, Võsa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Ärnlöv J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Holmes MV, Ingelsson E, Mälarstig A. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000281 (RETN) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Resistin (RETN) serum levels | blood protein measurement | 552,002 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000281/ScoringFiles/PGS000281.txt.gz |
| PGS000274 (PDGF_subunit_B) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Platelet-derived growth factor subunit B (PDGF_subunit_B) serum levels | blood protein measurement | 552,265 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000274/ScoringFiles/PGS000274.txt.gz |
| PGS000287 (TNF-R1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Tumor necrosis factor receptor 1 (TNF-R1) serum levels | blood protein measurement | 552,317 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000287/ScoringFiles/PGS000287.txt.gz |
| PGS000249 (IL-18) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Interleukin-18 (IL-18) serum levels | blood protein measurement | 552,186 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000249/ScoringFiles/PGS000249.txt.gz |
| PGS000266 (MMP-12) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Matrix metalloproteinase-12 (MMP-12) serum levels | blood protein measurement | 552,021 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000266/ScoringFiles/PGS000266.txt.gz |
| PGS000267 (MMP-3) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Matrix metalloproteinase-3 (MMP-3) serum levels | blood protein measurement | 552,328 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000267/ScoringFiles/PGS000267.txt.gz |
| PGS000277 (PSGL-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
P-selectin glycoprotein ligand 1 (PSGL-1) serum levels | blood protein measurement | 552,165 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000277/ScoringFiles/PGS000277.txt.gz |
| PGS000286 (TM) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Thrombomodulin (TM) serum levels | blood protein measurement | 552,241 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000286/ScoringFiles/PGS000286.txt.gz |
| PGS000292 (TRANCE) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
TNF-related activation-induced cytokine (TRANCE) serum levels | blood protein measurement | 552,090 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000292/ScoringFiles/PGS000292.txt.gz |
| PGS000255 (IL16) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Pro-interleukin-16 (IL16) serum levels | blood protein measurement | 551,884 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000255/ScoringFiles/PGS000255.txt.gz |
| PGS000283 (SPON1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Spondin-1 (SPON1) serum levels | blood protein measurement | 552,703 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000283/ScoringFiles/PGS000283.txt.gz |
| PGS000253 (IL-6RA) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Interleukin-6 receptor subunit alpha (IL-6RA) serum levels | blood protein measurement | 552,132 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000253/ScoringFiles/PGS000253.txt.gz |
| PGS000284 (ST2) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
ST2 protein (ST2) serum levels | blood protein measurement | 552,006 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000284/ScoringFiles/PGS000284.txt.gz |
| PGS000228 (CTSL1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Cathepsin L1 (CTSL1) serum levels | blood protein measurement | 552,084 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000228/ScoringFiles/PGS000228.txt.gz |
| PGS000224 (CHI3L1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Chitinase-3-like protein 1 (CHI3L1) serum levels | blood protein measurement | 552,106 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000224/ScoringFiles/PGS000224.txt.gz |
| PGS000234 (ECP) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Eosinophil cationic protein (ECP) serum levels | blood protein measurement | 553,046 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000234/ScoringFiles/PGS000234.txt.gz |
| PGS000235 (EGF) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Epidermal growth factor (EGF) serum levels | blood protein measurement | 553,163 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000235/ScoringFiles/PGS000235.txt.gz |
| PGS000262 (MB) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Myoglobin (MB) serum levels | blood protein measurement | 552,171 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000262/ScoringFiles/PGS000262.txt.gz |
| PGS000293 (U-PAR) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Urokinase plasminogen activator surface receptor (U-PAR) serum levels | blood protein measurement | 552,048 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000293/ScoringFiles/PGS000293.txt.gz |
| PGS000225 (CSF-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Macrophage colony-stimulating factor 1 (CSF-1) serum levels | blood protein measurement | 552,163 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000225/ScoringFiles/PGS000225.txt.gz |
| PGS000239 (FGF-23) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Fibroblast growth factor 23 (FGF-23) serum levels | blood protein measurement | 552,100 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000239/ScoringFiles/PGS000239.txt.gz |
| PGS000245 (HB-EGF) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Proheparin-binding EGF-like growth factor (HB-EGF) serum levels | blood protein measurement | 552,108 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000245/ScoringFiles/PGS000245.txt.gz |
| PGS000278 (PTX3) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Pentraxin-related protein PTX3 (PTX3) serum levels | blood protein measurement | 552,474 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000278/ScoringFiles/PGS000278.txt.gz |
| PGS000236 (ESM-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Endothelial cell-specific molecule 1 (ESM-1) serum levels | blood protein measurement | 553,240 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000236/ScoringFiles/PGS000236.txt.gz |
| PGS000270 (NT-pro_BNP) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
N-terminal prohormone brain natriuretic peptide (NT-pro_BNP) serum levels | blood protein measurement | 554,137 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000270/ScoringFiles/PGS000270.txt.gz |
| PGS000243 (GDF-15) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Growth/differentiation factor 15 (GDF-15) serum levels | blood protein measurement | 552,228 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000243/ScoringFiles/PGS000243.txt.gz |
| PGS000218 (AGRP) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Agouti-related protein (AGRP) serum levels | blood protein measurement | 552,121 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000218/ScoringFiles/PGS000218.txt.gz |
| PGS000259 (LEP) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Leptin (LEP) serum levels | blood protein measurement | 552,110 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000259/ScoringFiles/PGS000259.txt.gz |
| PGS000265 (MMP-10) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Matrix metalloproteinase-10 (MMP-10) serum levels | blood protein measurement | 552,072 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000265/ScoringFiles/PGS000265.txt.gz |
| PGS000282 (SCF) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Stem cell factor (SCF) serum levels | blood protein measurement | 552,420 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000282/ScoringFiles/PGS000282.txt.gz |
| PGS000223 (CD40) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Tumor necrosis factor receptor superfamily member 5 (CD40) serum levels | blood protein measurement | 552,187 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000223/ScoringFiles/PGS000223.txt.gz |
| PGS000244 (GH) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Growth hormone (GH) serum levels | blood protein measurement | 552,236 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000244/ScoringFiles/PGS000244.txt.gz |
| PGS000241 (GAL) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Galanin peptides (GAL) serum levels | blood protein measurement | 553,548 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000241/ScoringFiles/PGS000241.txt.gz |
| PGS000226 (CSTB) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Cystatin-B (CSTB) serum levels | blood protein measurement | 552,195 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000226/ScoringFiles/PGS000226.txt.gz |
| PGS000232 (CXCL6) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
C-X-C motif chemokine 6 (CXCL6) serum levels | blood protein measurement | 552,061 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000232/ScoringFiles/PGS000232.txt.gz |
| PGS000238 (FAS) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Tumor necrosis factor receptor superfamily member 6 (FAS) serum levels | blood protein measurement | 552,335 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000238/ScoringFiles/PGS000238.txt.gz |
| PGS000231 (CXCL16) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
C-X-C motif chemokine 16 (CXCL16) serum levels | blood protein measurement | 552,241 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000231/ScoringFiles/PGS000231.txt.gz |
| PGS000248 (HSP_27) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Heat shock 27 kDa protein (HSP_27) serum levels | blood protein measurement | 552,212 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000248/ScoringFiles/PGS000248.txt.gz |
| PGS000252 (IL-6) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Interleukin-6 (IL-6) serum levels | blood protein measurement | 552,426 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000252/ScoringFiles/PGS000252.txt.gz |
| PGS000254 (IL-8) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Interleukin-8 (IL-8) serum levels | blood protein measurement | 551,990 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000254/ScoringFiles/PGS000254.txt.gz |
| PGS000263 (MCP-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Monocyte chemotactic protein 1 (MCP-1) serum levels | blood protein measurement | 552,000 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000263/ScoringFiles/PGS000263.txt.gz |
| PGS000269 (MPO) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Myeloperoxidase (MPO) serum levels | blood protein measurement | 552,278 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000269/ScoringFiles/PGS000269.txt.gz |
| PGS000290 (TRAIL) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
TNF-related apoptosis-inducing ligand (TRAIL) serum levels | blood protein measurement | 552,279 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000290/ScoringFiles/PGS000290.txt.gz |
| PGS000247 (hK11) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Kallikrein-11 (hK11) serum levels | blood protein measurement | 553,239 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000247/ScoringFiles/PGS000247.txt.gz |
| PGS000237 (FABP4) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Fatty acid-binding protein, adipocyte (FABP4) serum levels | blood protein measurement | 552,343 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000237/ScoringFiles/PGS000237.txt.gz |
| PGS000219 (CA-125) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Ovarian cancer-related tumor marker CA 125 (CA-125) serum levels | blood protein measurement | 553,819 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000219/ScoringFiles/PGS000219.txt.gz |
| PGS000220 (CCL20) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
C-C motif chemokine 20 (CCL20) serum levels | blood protein measurement | 551,989 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000220/ScoringFiles/PGS000220.txt.gz |
| PGS000229 (CX3CL1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Fractalkine (CX3CL1) serum levels | blood protein measurement | 552,274 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000229/ScoringFiles/PGS000229.txt.gz |
| PGS000233 (Dkk-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Dickkopf-related protein 1 (Dkk-1) serum levels | blood protein measurement | 552,067 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000233/ScoringFiles/PGS000233.txt.gz |
| PGS000250 (IL-1ra) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Interleukin-1 receptor antagonist protein (IL-1ra) serum levels | blood protein measurement | 551,917 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000250/ScoringFiles/PGS000250.txt.gz |
| PGS000251 (IL-27) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Interleukin-27 (IL-27) serum levels | blood protein measurement | 552,026 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000251/ScoringFiles/PGS000251.txt.gz |
| PGS000258 (KLK6) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Kallikrein-6 (KLK6) serum levels | blood protein measurement | 552,053 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000258/ScoringFiles/PGS000258.txt.gz |
| PGS000264 (MMP-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Matrix metalloproteinase-1 (MMP-1) serum levels | blood protein measurement | 552,116 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000264/ScoringFiles/PGS000264.txt.gz |
| PGS000268 (MMP-7) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Matrix metalloproteinase-7 (MMP-7) serum levels | blood protein measurement | 552,052 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000268/ScoringFiles/PGS000268.txt.gz |
| PGS000276 (PlGF) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Placenta growth factor (PlGF) serum levels | blood protein measurement | 552,275 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000276/ScoringFiles/PGS000276.txt.gz |
| PGS000279 (RAGE) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Receptor for advanced glycosylation end products (RAGE) serum levels | blood protein measurement | 552,298 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000279/ScoringFiles/PGS000279.txt.gz |
| PGS000285 (TF) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Tissue factor (TF) serum levels | blood protein measurement | 552,228 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000285/ScoringFiles/PGS000285.txt.gz |
| PGS000288 (TNF-R2) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Tumor necrosis factor receptor 2 (TNF-R2) serum levels | blood protein measurement | 552,185 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000288/ScoringFiles/PGS000288.txt.gz |
| PGS000294 (VEGF-A) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Vascular endothelial growth factor A (VEGF-A) serum levels | blood protein measurement | 552,070 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000294/ScoringFiles/PGS000294.txt.gz |
| PGS000217 (ADM) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Adrenomedullin (ADM) serum levels | blood protein measurement | 552,254 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000217/ScoringFiles/PGS000217.txt.gz |
| PGS000221 (CCL3) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
C-C motif chemokine 3 (CCL3) serum levels | blood protein measurement | 552,347 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000221/ScoringFiles/PGS000221.txt.gz |
| PGS000222 (CCL4) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
C-C motif chemokine 4 (CCL4) serum levels | blood protein measurement | 552,214 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000222/ScoringFiles/PGS000222.txt.gz |
| PGS000227 (CTSD) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Cathepsin D (CTSD) serum levels | blood protein measurement | 552,134 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000227/ScoringFiles/PGS000227.txt.gz |
| PGS000230 (CXCL1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
C-X-C motif chemokine 1 (CXCL1) serum levels | blood protein measurement | 552,234 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000230/ScoringFiles/PGS000230.txt.gz |
| PGS000240 (FS) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Follistatin (FS) serum levels | blood protein measurement | 552,138 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000240/ScoringFiles/PGS000240.txt.gz |
| PGS000242 (Gal-3) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Galectin-3 (Gal-3) serum levels | blood protein measurement | 552,282 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000242/ScoringFiles/PGS000242.txt.gz |
| PGS000246 (HGF) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Hepatocyte growth factor (HGF) serum levels | blood protein measurement | 552,104 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000246/ScoringFiles/PGS000246.txt.gz |
| PGS000256 (ITGB1BP2) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Melusin (ITGB1BP2) serum levels | blood protein measurement | 552,423 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000256/ScoringFiles/PGS000256.txt.gz |
| PGS000257 (KIM-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Kidney injury molecule 1 (KIM-1) serum levels | blood protein measurement | 552,062 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000257/ScoringFiles/PGS000257.txt.gz |
| PGS000260 (LOX-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Lectin-like oxidized LDL receptor 1 (LOX-1) serum levels | blood protein measurement | 552,045 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000260/ScoringFiles/PGS000260.txt.gz |
| PGS000261 (mAmP) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Membrane-bound aminopeptidase P (mAmP) serum levels | blood protein measurement | 553,070 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000261/ScoringFiles/PGS000261.txt.gz |
| PGS000271 (OPG) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Osteoprotegerin (OPG) serum levels | blood protein measurement | 552,205 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000271/ScoringFiles/PGS000271.txt.gz |
| PGS000272 (PAPPA) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Pappalysin-1 (PAPPA) serum levels | blood protein measurement | 552,298 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000272/ScoringFiles/PGS000272.txt.gz |
| PGS000273 (PAR-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Proteinase-activated receptor 1 (PAR-1) serum levels | blood protein measurement | 552,202 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000273/ScoringFiles/PGS000273.txt.gz |
| PGS000275 (PECAM-1) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Platelet endothelial cell adhesion molecule (PECAM-1) serum levels | blood protein measurement | 552,010 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000275/ScoringFiles/PGS000275.txt.gz |
| PGS000280 (REN) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Renin (REN) serum levels | blood protein measurement | 552,078 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000280/ScoringFiles/PGS000280.txt.gz |
| PGS000289 (TNFSF14) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) serum levels | blood protein measurement | 552,048 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000289/ScoringFiles/PGS000289.txt.gz |
| PGS000291 (TRAIL-R2) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) serum levels | blood protein measurement | 552,198 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000291/ScoringFiles/PGS000291.txt.gz |
| PGS000295 (VEGF-D) |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Vascular endothelial growth factor D (VEGF-D) serum levels | blood protein measurement | 551,905 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000295/ScoringFiles/PGS000295.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000665 | PGS000244 (GH) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Growth hormone (GH) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.00246 R²: 0.32546 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000671 | PGS000276 (PlGF) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Placenta growth factor (PlGF) serum levels | — | — | R²: 0.09579 R² difference (PGS+covariates vs. covariates only): 0.00679 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000666 | PGS000254 (IL-8) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Interleukin-8 (IL-8) serum levels | — | — | R²: 0.03298 R² difference (PGS+covariates vs. covariates only): 0.00298 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000667 | PGS000256 (ITGB1BP2) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Melusin (ITGB1BP2) serum levels | — | — | R²: 0.00624 R² difference (PGS+covariates vs. covariates only): 0.00324 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000668 | PGS000274 (PDGF_subunit_B) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Platelet-derived growth factor subunit B (PDGF_subunit_B) serum levels | — | — | R²: 0.00734 R² difference (PGS+covariates vs. covariates only): 0.00434 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000669 | PGS000225 (CSF-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Macrophage colony-stimulating factor 1 (CSF-1) serum levels | — | — | R²: 0.01849 R² difference (PGS+covariates vs. covariates only): 0.00549 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000672 | PGS000259 (LEP) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Leptin (LEP) serum levels | — | — | R²: 0.32983 R² difference (PGS+covariates vs. covariates only): 0.00683 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000673 | PGS000280 (REN) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Renin (REN) serum levels | — | — | R²: 0.08537 R² difference (PGS+covariates vs. covariates only): 0.00737 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000674 | PGS000218 (AGRP) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Agouti-related protein (AGRP) serum levels | — | — | R²: 0.0215 R² difference (PGS+covariates vs. covariates only): 0.0075 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000675 | PGS000252 (IL-6) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Interleukin-6 (IL-6) serum levels | — | — | R²: 0.01995 R² difference (PGS+covariates vs. covariates only): 0.00795 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000676 | PGS000287 (TNF-R1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Tumor necrosis factor receptor 1 (TNF-R1) serum levels | — | — | R²: 0.06801 R² difference (PGS+covariates vs. covariates only): 0.00801 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000677 | PGS000237 (FABP4) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Fatty acid-binding protein, adipocyte (FABP4) serum levels | — | — | R²: 0.14804 R² difference (PGS+covariates vs. covariates only): 0.00804 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000678 | PGS000273 (PAR-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Proteinase-activated receptor 1 (PAR-1) serum levels | — | — | R²: 0.01206 R² difference (PGS+covariates vs. covariates only): 0.00906 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000679 | PGS000236 (ESM-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Endothelial cell-specific molecule 1 (ESM-1) serum levels | — | — | R²: 0.03924 R² difference (PGS+covariates vs. covariates only): 0.00924 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000680 | PGS000235 (EGF) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Epidermal growth factor (EGF) serum levels | — | — | R²: 0.01262 R² difference (PGS+covariates vs. covariates only): 0.00962 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000681 | PGS000260 (LOX-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Lectin-like oxidized LDL receptor 1 (LOX-1) serum levels | — | — | R²: 0.01745 R² difference (PGS+covariates vs. covariates only): 0.01045 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000682 | PGS000277 (PSGL-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: P-selectin glycoprotein ligand 1 (PSGL-1) serum levels | — | — | R²: 0.01086 R² difference (PGS+covariates vs. covariates only): 0.01086 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000683 | PGS000262 (MB) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Myoglobin (MB) serum levels | — | — | R²: 0.14211 R² difference (PGS+covariates vs. covariates only): 0.01111 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000684 | PGS000240 (FS) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Follistatin (FS) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.01152 R²: 0.05152 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000686 | PGS000246 (HGF) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Hepatocyte growth factor (HGF) serum levels | — | — | R²: 0.0741 R² difference (PGS+covariates vs. covariates only): 0.0131 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000687 | PGS000219 (CA-125) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Ovarian cancer-related tumor marker CA 125 (CA-125) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.01315 R²: 0.02315 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000688 | PGS000288 (TNF-R2) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Tumor necrosis factor receptor 2 (TNF-R2) serum levels | — | — | R²: 0.05136 R² difference (PGS+covariates vs. covariates only): 0.01336 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000689 | PGS000217 (ADM) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Adrenomedullin (ADM) serum levels | — | — | R²: 0.07313 R² difference (PGS+covariates vs. covariates only): 0.01413 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000690 | PGS000293 (U-PAR) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Urokinase plasminogen activator surface receptor (U-PAR) serum levels | — | — | R²: 0.03628 R² difference (PGS+covariates vs. covariates only): 0.01428 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000691 | PGS000231 (CXCL16) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: C-X-C motif chemokine 16 (CXCL16) serum levels | — | — | R²: 0.01734 R² difference (PGS+covariates vs. covariates only): 0.01434 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000692 | PGS000239 (FGF-23) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Fibroblast growth factor 23 (FGF-23) serum levels | — | — | R²: 0.01903 R² difference (PGS+covariates vs. covariates only): 0.01503 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000693 | PGS000247 (hK11) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Kallikrein-11 (hK11) serum levels | — | — | R²: 0.03621 R² difference (PGS+covariates vs. covariates only): 0.01721 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000694 | PGS000261 (mAmP) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Membrane-bound aminopeptidase P (mAmP) serum levels | — | — | R²: 0.02085 R² difference (PGS+covariates vs. covariates only): 0.01785 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000695 | PGS000227 (CTSD) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Cathepsin D (CTSD) serum levels | — | — | R²: 0.09886 R² difference (PGS+covariates vs. covariates only): 0.01786 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000696 | PGS000258 (KLK6) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Kallikrein-6 (KLK6) serum levels | — | — | R²: 0.03607 R² difference (PGS+covariates vs. covariates only): 0.01807 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000697 | PGS000234 (ECP) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Eosinophil cationic protein (ECP) serum levels | — | — | R²: 0.023 R² difference (PGS+covariates vs. covariates only): 0.019 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000698 | PGS000233 (Dkk-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Dickkopf-related protein 1 (Dkk-1) serum levels | — | — | R²: 0.02226 R² difference (PGS+covariates vs. covariates only): 0.01926 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000699 | PGS000271 (OPG) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Osteoprotegerin (OPG) serum levels | — | — | R²: 0.09428 R² difference (PGS+covariates vs. covariates only): 0.02128 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000700 | PGS000295 (VEGF-D) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Vascular endothelial growth factor D (VEGF-D) serum levels | — | — | R²: 0.0429 R² difference (PGS+covariates vs. covariates only): 0.0219 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000701 | PGS000268 (MMP-7) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Matrix metalloproteinase-7 (MMP-7) serum levels | — | — | R²: 0.0571 R² difference (PGS+covariates vs. covariates only): 0.0221 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000702 | PGS000263 (MCP-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Monocyte chemotactic protein 1 (MCP-1) serum levels | — | — | R²: 0.04833 R² difference (PGS+covariates vs. covariates only): 0.02333 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000703 | PGS000229 (CX3CL1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Fractalkine (CX3CL1) serum levels | — | — | R²: 0.03603 R² difference (PGS+covariates vs. covariates only): 0.02403 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000704 | PGS000238 (FAS) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Tumor necrosis factor receptor superfamily member 6 (FAS) serum levels | — | — | R²: 0.08826 R² difference (PGS+covariates vs. covariates only): 0.02626 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000705 | PGS000279 (RAGE) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Receptor for advanced glycosylation end products (RAGE) serum levels | — | — | R²: 0.04312 R² difference (PGS+covariates vs. covariates only): 0.02712 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000706 | PGS000283 (SPON1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Spondin-1 (SPON1) serum levels | — | — | R²: 0.06873 R² difference (PGS+covariates vs. covariates only): 0.02773 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000708 | PGS000278 (PTX3) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Pentraxin-related protein PTX3 (PTX3) serum levels | — | — | R²: 0.03012 R² difference (PGS+covariates vs. covariates only): 0.02812 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000709 | PGS000281 (RETN) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Resistin (RETN) serum levels | — | — | R²: 0.04427 R² difference (PGS+covariates vs. covariates only): 0.03327 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000710 | PGS000286 (TM) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Thrombomodulin (TM) serum levels | — | — | R²: 0.08819 R² difference (PGS+covariates vs. covariates only): 0.03619 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000711 | PGS000249 (IL-18) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Interleukin-18 (IL-18) serum levels | — | — | R²: 0.08863 R² difference (PGS+covariates vs. covariates only): 0.03763 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000712 | PGS000228 (CTSL1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Cathepsin L1 (CTSL1) serum levels | — | — | R²: 0.09752 R² difference (PGS+covariates vs. covariates only): 0.03852 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000713 | PGS000289 (TNFSF14) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Tumor necrosis factor ligand superfamily member 14 (TNFSF14) serum levels | — | — | R²: 0.04311 R² difference (PGS+covariates vs. covariates only): 0.03911 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000714 | PGS000250 (IL-1ra) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Interleukin-1 receptor antagonist protein (IL-1ra) serum levels | — | — | R²: 0.05359 R² difference (PGS+covariates vs. covariates only): 0.03959 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000715 | PGS000292 (TRANCE) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: TNF-related activation-induced cytokine (TRANCE) serum levels | — | — | R²: 0.0487 R² difference (PGS+covariates vs. covariates only): 0.0427 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000716 | PGS000291 (TRAIL-R2) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.04464 R²: 0.05164 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000717 | PGS000223 (CD40) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Tumor necrosis factor receptor superfamily member 5 (CD40) serum levels | — | — | R²: 0.04728 R² difference (PGS+covariates vs. covariates only): 0.04528 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000718 | PGS000243 (GDF-15) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Growth/differentiation factor 15 (GDF-15) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.04577 R²: 0.19577 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000719 | PGS000269 (MPO) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Myeloperoxidase (MPO) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.04865 R²: 0.05565 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000720 | PGS000272 (PAPPA) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Pappalysin-1 (PAPPA) serum levels | — | — | R²: 0.14698 R² difference (PGS+covariates vs. covariates only): 0.04998 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000721 | PGS000242 (Gal-3) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Galectin-3 (Gal-3) serum levels | — | — | R²: 0.11502 R² difference (PGS+covariates vs. covariates only): 0.05002 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000722 | PGS000265 (MMP-10) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Matrix metalloproteinase-10 (MMP-10) serum levels | — | — | R²: 0.0618 R² difference (PGS+covariates vs. covariates only): 0.0518 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000724 | PGS000290 (TRAIL) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: TNF-related apoptosis-inducing ligand (TRAIL) serum levels | — | — | R²: 0.11259 R² difference (PGS+covariates vs. covariates only): 0.05259 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000725 | PGS000275 (PECAM-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Platelet endothelial cell adhesion molecule (PECAM-1) serum levels | — | — | R²: 0.07059 R² difference (PGS+covariates vs. covariates only): 0.05759 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000726 | PGS000221 (CCL3) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: C-C motif chemokine 3 (CCL3) serum levels | — | — | R²: 0.10469 R² difference (PGS+covariates vs. covariates only): 0.05869 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000727 | PGS000285 (TF) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Tissue factor (TF) serum levels | — | — | R²: 0.10251 R² difference (PGS+covariates vs. covariates only): 0.06551 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000728 | PGS000267 (MMP-3) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Matrix metalloproteinase-3 (MMP-3) serum levels | — | — | R²: 0.40253 R² difference (PGS+covariates vs. covariates only): 0.06753 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000729 | PGS000224 (CHI3L1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Chitinase-3-like protein 1 (CHI3L1) serum levels | — | — | R²: 0.15424 R² difference (PGS+covariates vs. covariates only): 0.07924 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000730 | PGS000230 (CXCL1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: C-X-C motif chemokine 1 (CXCL1) serum levels | — | — | R²: 0.08781 R² difference (PGS+covariates vs. covariates only): 0.07981 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000731 | PGS000266 (MMP-12) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Matrix metalloproteinase-12 (MMP-12) serum levels | — | — | R²: 0.08867 R² difference (PGS+covariates vs. covariates only): 0.08867 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000732 | PGS000294 (VEGF-A) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Vascular endothelial growth factor A (VEGF-A) serum levels | — | — | R²: 0.10967 R² difference (PGS+covariates vs. covariates only): 0.08967 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000733 | PGS000251 (IL-27) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Interleukin-27 (IL-27) serum levels | — | — | R²: 0.11711 R² difference (PGS+covariates vs. covariates only): 0.09911 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000734 | PGS000226 (CSTB) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Cystatin-B (CSTB) serum levels | — | — | R²: 0.14472 R² difference (PGS+covariates vs. covariates only): 0.10072 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000735 | PGS000248 (HSP_27) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Heat shock 27 kDa protein (HSP_27) serum levels | — | — | R²: 0.10996 R² difference (PGS+covariates vs. covariates only): 0.10196 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000736 | PGS000222 (CCL4) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: C-C motif chemokine 4 (CCL4) serum levels | — | — | R²: 0.13833 R² difference (PGS+covariates vs. covariates only): 0.11033 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000737 | PGS000255 (IL16) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Pro-interleukin-16 (IL16) serum levels | — | — | R²: 0.1446 R² difference (PGS+covariates vs. covariates only): 0.1136 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000738 | PGS000264 (MMP-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Matrix metalloproteinase-1 (MMP-1) serum levels | — | — | R²: 0.2112 R² difference (PGS+covariates vs. covariates only): 0.1192 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000739 | PGS000257 (KIM-1) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Kidney injury molecule 1 (KIM-1) serum levels | — | — | R²: 0.22579 R² difference (PGS+covariates vs. covariates only): 0.13579 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000740 | PGS000232 (CXCL6) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: C-X-C motif chemokine 6 (CXCL6) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.1496 R²: 0.1536 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000742 | PGS000253 (IL-6RA) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Interleukin-6 receptor subunit alpha (IL-6RA) serum levels | — | — | R²: 0.31718 R² difference (PGS+covariates vs. covariates only): 0.28118 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000664 | PGS000270 (NT-pro_BNP) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: N-terminal prohormone brain natriuretic peptide (NT-pro_BNP) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.00108 R²: 0.07108 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000670 | PGS000245 (HB-EGF) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Proheparin-binding EGF-like growth factor (HB-EGF) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.00607 R²: 0.00807 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000685 | PGS000220 (CCL20) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: C-C motif chemokine 20 (CCL20) serum levels | — | — | R² difference (PGS+covariates vs. covariates only): 0.01158 R²: 0.02158 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000707 | PGS000241 (GAL) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Galanin peptides (GAL) serum levels | — | — | R²: 0.07696 R² difference (PGS+covariates vs. covariates only): 0.02796 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000723 | PGS000282 (SCF) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: Stem cell factor (SCF) serum levels | — | — | R²: 0.05956 R² difference (PGS+covariates vs. covariates only): 0.05256 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
| PPM000741 | PGS000284 (ST2) |
PSS000364| European Ancestry| 4,678 individuals |
PGP000089 | Folkersen L et al. Nat Metab (2020) |
Reported Trait: ST2 protein (ST2) serum levels | — | — | R²: 0.32939 R² difference (PGS+covariates vs. covariates only): 0.19039 |
age + sex + 10 genetic PCs | The main manuscript further reports scores divided into genome-wide significant loci (major loci) and remaining polygenic loci, but this performance metric just reports the sum of both. |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000364 | — | — | 4,678 individuals | — | European (Swedish) |
— | MDC | — |