PGS Publication: PGP000097

Publication Information (EuropePMC)
Title Sex-specific genetic effects across biomarkers.
PubMed ID 32873964(Europe PMC)
doi 10.1038/s41431-020-00712-w
Publication Date Sept. 1, 2020
Journal Eur J Hum Genet
Author(s) Flynn E, Tanigawa Y, Rodriguez F, Altman RB, Sinnott-Armstrong N, Rivas MA.
Released in PGS Catalog: Sept. 4, 2020

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000321
(snpnet_Testosterone_combined)
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Serum testosterone levels testosterone measurement 7,319
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000321/ScoringFiles/PGS000321.txt.gz
PGS000322
(snpnet_Testosterone_female-specific)
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Serum testosterone levels in females testosterone measurement,
female		 7,168
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000322/ScoringFiles/PGS000322.txt.gz
PGS000323
(snpnet_Testosterone_male-specific)
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Serum testosterone levels in males testosterone measurement,
male		 8,235
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000323/ScoringFiles/PGS000323.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000866 PGS000323
(snpnet_Testosterone_male-specific)
 PSS000421|
European Ancestry|
28,640 individuals
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Reported Trait: Serum testosterone levels in females — — R²: 0.023 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array —
PPM000865 PGS000321
(snpnet_Testosterone_combined)
 PSS000421|
European Ancestry|
28,640 individuals
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Reported Trait: Serum testosterone levels in females — — R²: 0.13 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array —
PPM000864 PGS000322
(snpnet_Testosterone_female-specific)
 PSS000421|
European Ancestry|
28,640 individuals
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Reported Trait: Serum testosterone levels in females — — R²: 0.18 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array —
PPM000863 PGS000322
(snpnet_Testosterone_female-specific)
 PSS000422|
European Ancestry|
28,601 individuals
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Reported Trait: Serum testosterone levels in males — — R²: 0.02 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array —
PPM000862 PGS000321
(snpnet_Testosterone_combined)
 PSS000422|
European Ancestry|
28,601 individuals
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Reported Trait: Serum testosterone levels in males — — R²: 0.21 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array —
PPM000861 PGS000323
(snpnet_Testosterone_male-specific)
 PSS000422|
European Ancestry|
28,601 individuals
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Reported Trait: Serum testosterone levels in males — — R²: 0.31 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000421 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. — 28,640 individuals,
0.0 % Male samples
 — European — UKB —
PSS000422 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. — 28,601 individuals,
100.0 % Male samples
 — European — UKB —