PGS Publication: PGP000111

Publication Information (EuropePMC)
Title Evaluation of a Genetic Risk Score for Diagnosis of Psoriatic Arthritis.
PubMed ID 32462110(Europe PMC)
doi 10.1177/2475530320910814
Publication Date March 4, 2020
Journal J Psoriasis Psoriatic Arthritis
Author(s) Smith MP, Ly K, Thibodeaux Q, Beck K, Yang E, Sanchez I, Nititham J, Bhutani T, Liao W.
Released in PGS Catalog: Nov. 20, 2020

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000342
(wGRS_PsA)
 PGP000111 |
Smith MP et al. J Psoriasis Psoriatic Arthritis (2020)
 Psoriatic arthritis psoriatic arthritis 11
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000342/ScoringFiles/PGS000342.txt.gz
PGS000343
(wGRS_PsA_HLA)
 PGP000111 |
Smith MP et al. J Psoriasis Psoriatic Arthritis (2020)
 Psoriatic arthritis psoriatic arthritis 5
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000343/ScoringFiles/PGS000343.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000972 PGS000343
(wGRS_PsA_HLA)
 PSS000490|
Ancestry Not Reported|
543 individuals
 PGP000111 |
Smith MP et al. J Psoriasis Psoriatic Arthritis (2020)
 Reported Trait: Psoriatic arthritis — AUROC: 0.569 [0.513, 0.625] — — —
PPM000971 PGS000342
(wGRS_PsA)
 PSS000490|
Ancestry Not Reported|
543 individuals
 PGP000111 |
Smith MP et al. J Psoriasis Psoriatic Arthritis (2020)
 Reported Trait: Psoriatic arthritis — AUROC: 0.562 [0.506, 0.618] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000490 Cases included physician-confirmed psoriatic arthritis (PsA). Controls inclded individuals with psoriasis with no history of joint symptoms (psoriasis only - PsO). —
[
  • 140 cases
  • , 403 controls
]
 — NR — NR —