PGS Publication: PGP000140

Publication Information (EuropePMC)
Title Separating the genetics of childhood and adult obesity: a validation study of genetic scores for body mass index in adolescence and adulthood in the HUNT Study.
PubMed ID 33276378(Europe PMC)
doi 10.1093/hmg/ddaa256
Publication Date Dec. 4, 2020
Journal Hum Mol Genet
Author(s) Brandkvist M, Bjørngaard JH, Ødegård RA, Åsvold BO, Smith GD, Brumpton B, Hveem K, Richardson TG, Vie GÅ.
Released in PGS Catalog: Feb. 23, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000716
(PGS295_elbs)
 PGP000132 |
Richardson TG et al. BMJ (2020)
 Early life body size comparative body size at age 10, self-reported,
body mass index		 295
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000716/ScoringFiles/PGS000716.txt.gz
PGS000717
(PGS557_albs)
 PGP000132 |
Richardson TG et al. BMJ (2020)
 Adult life body size body mass index 557
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000717/ScoringFiles/PGS000717.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001708 PGS000716
(PGS295_elbs)
 PSS000883|
European Ancestry|
62,541 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 30-69.9 — AUROC: 0.569 [0.564, 0.574] — — Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001709 PGS000716
(PGS295_elbs)
 PSS000876|
European Ancestry|
3,124 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 12-15.9 — AUROC: 0.656 [0.626, 0.686] — — Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001710 PGS000716
(PGS295_elbs)
 PSS000878|
European Ancestry|
2,896 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 16-17.9 — AUROC: 0.623 [0.589, 0.657] — — Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001711 PGS000716
(PGS295_elbs)
 PSS000880|
European Ancestry|
12,179 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 18-23.9 — AUROC: 0.601 [0.589, 0.612] — — Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001712 PGS000716
(PGS295_elbs)
 PSS000882|
European Ancestry|
17,139 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 14-29.9 — AUROC: 0.591 [0.582, 0.6] — — Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001713 PGS000716
(PGS295_elbs)
 PSS000884|
European Ancestry|
62,541 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 30-69.9 — AUROC: 0.568 [0.563, 0.573] — — Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001714 PGS000717
(PGS557_albs)
 PSS000875|
European Ancestry|
3,124 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 12-15.9 — AUROC: 0.664 [0.574, 0.753] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001715 PGS000717
(PGS557_albs)
 PSS000877|
European Ancestry|
2,896 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 16-17.9 — AUROC: 0.691 [0.589, 0.793] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001716 PGS000717
(PGS557_albs)
 PSS000879|
European Ancestry|
12,179 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 18-23.9 — AUROC: 0.624 [0.601, 0.646] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001717 PGS000717
(PGS557_albs)
 PSS000881|
European Ancestry|
17,139 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 24-29.9 — AUROC: 0.623 [0.607, 0.639] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001719 PGS000717
(PGS557_albs)
 PSS000876|
European Ancestry|
3,124 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 12-15.9 — AUROC: 0.587 [0.556, 0.618] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001720 PGS000717
(PGS557_albs)
 PSS000878|
European Ancestry|
2,896 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 16-17.9 — AUROC: 0.615 [0.58, 0.649] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001722 PGS000717
(PGS557_albs)
 PSS000882|
European Ancestry|
17,139 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 14-29.9 — AUROC: 0.598 [0.589, 0.607] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001723 PGS000717
(PGS557_albs)
 PSS000884|
European Ancestry|
62,541 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 30-69.9 — AUROC: 0.582 [0.578, 0.587] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001707 PGS000716
(PGS295_elbs)
 PSS000879|
European Ancestry|
12,179 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 18-23.9 — AUROC: 0.618 [0.594, 0.641] — — Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001718 PGS000717
(PGS557_albs)
 PSS000883|
European Ancestry|
62,541 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 30-69.9 — AUROC: 0.597 [0.591, 0.602] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001687 PGS000716
(PGS295_elbs)
 PSS000879|
European Ancestry|
12,179 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 18-23.9 — AUROC: 0.619 [0.596, 0.643] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001688 PGS000716
(PGS295_elbs)
 PSS000881|
European Ancestry|
17,139 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 24-29.9 — AUROC: 0.602 [0.585, 0.618] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001689 PGS000716
(PGS295_elbs)
 PSS000883|
European Ancestry|
62,541 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 30-69.9 — AUROC: 0.569 [0.564, 0.574] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001690 PGS000716
(PGS295_elbs)
 PSS000876|
European Ancestry|
3,124 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 12-15.9 — AUROC: 0.658 [0.628, 0.687] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001691 PGS000716
(PGS295_elbs)
 PSS000878|
European Ancestry|
2,896 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 16-17.9 — AUROC: 0.624 [0.589, 0.658] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001692 PGS000716
(PGS295_elbs)
 PSS000880|
European Ancestry|
12,179 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 18-23.9 — AUROC: 0.602 [0.59, 0.613] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001693 PGS000716
(PGS295_elbs)
 PSS000882|
European Ancestry|
17,139 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 14-29.9 — AUROC: 0.591 [0.582, 0.6] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001695 PGS000717
(PGS557_albs)
 PSS000875|
European Ancestry|
3,124 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 12-15.9 — AUROC: 0.66 [0.57, 0.75] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001696 PGS000717
(PGS557_albs)
 PSS000877|
European Ancestry|
2,896 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 16-17.9 — AUROC: 0.661 [0.551, 0.77] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001699 PGS000717
(PGS557_albs)
 PSS000883|
European Ancestry|
62,541 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 30-69.9 — AUROC: 0.6 [0.595, 0.605] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001702 PGS000717
(PGS557_albs)
 PSS000880|
European Ancestry|
12,179 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 18-23.9 — AUROC: 0.595 [0.583, 0.607] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001703 PGS000717
(PGS557_albs)
 PSS000882|
European Ancestry|
17,139 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 14-29.9 — AUROC: 0.602 [0.593, 0.611] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001704 PGS000717
(PGS557_albs)
 PSS000884|
European Ancestry|
62,541 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 30-69.9 — AUROC: 0.585 [0.58, 0.589] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001705 PGS000716
(PGS295_elbs)
 PSS000875|
European Ancestry|
3,124 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 12-15.9 — AUROC: 0.739 [0.667, 0.811] — — Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001706 PGS000716
(PGS295_elbs)
 PSS000877|
European Ancestry|
2,896 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 16-17.9 — AUROC: 0.66 [0.566, 0.754] — — Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001721 PGS000717
(PGS557_albs)
 PSS000880|
European Ancestry|
12,179 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 18-23.9 — AUROC: 0.592 [0.58, 0.604] — — Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001685 PGS000716
(PGS295_elbs)
 PSS000875|
European Ancestry|
3,124 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 12-15.9 — AUROC: 0.735 [0.663, 0.806] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001686 PGS000716
(PGS295_elbs)
 PSS000877|
European Ancestry|
2,896 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 16-17.9 — AUROC: 0.672 [0.577, 0.766] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001694 PGS000716
(PGS295_elbs)
 PSS000884|
European Ancestry|
62,541 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 30-69.9 — AUROC: 0.568 [0.563, 0.573] — — Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001697 PGS000717
(PGS557_albs)
 PSS000879|
European Ancestry|
12,179 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 18-23.9 — AUROC: 0.629 [0.606, 0.652] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001698 PGS000717
(PGS557_albs)
 PSS000881|
European Ancestry|
17,139 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Obesity in individuals aged 24-29.9 — AUROC: 0.627 [0.611, 0.643] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001700 PGS000717
(PGS557_albs)
 PSS000876|
European Ancestry|
3,124 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 12-15.9 — AUROC: 0.591 [0.559, 0.623] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001701 PGS000717
(PGS557_albs)
 PSS000878|
European Ancestry|
2,896 individuals
 PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.		 Reported Trait: Overweight in individuals aged 16-17.9 — AUROC: 0.618 [0.583, 0.653] — — Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000875 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force. —
[
  • 37 cases
  • , 3,087 controls
]
 — European — HUNT —
PSS000876 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force. —
[
  • 344 cases
  • , 2,780 controls
]
 — European — HUNT —
PSS000877 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force. —
[
  • 30 cases
  • , 2,866 controls
]
 — European — HUNT —
PSS000878 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force. —
[
  • 274 cases
  • , 2,622 controls
]
 — European — HUNT —
PSS000879 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. —
[
  • 542 cases
  • , 11,637 controls
]
 — European — HUNT —
PSS000880 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. —
[
  • 2,898 cases
  • , 9,281 controls
]
 — European — HUNT —
PSS000881 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. —
[
  • 1,240 cases
  • , 15,899 controls
]
 — European — HUNT —
PSS000882 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. —
[
  • 5,775 cases
  • , 11,364 controls
]
 — European — HUNT —
PSS000883 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. —
[
  • 15,112 cases
  • , 47,429 controls
]
 — European — HUNT —
PSS000884 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. —
[
  • 43,408 cases
  • , 19,133 controls
]
 — European — HUNT —