PGS Publication: PGP000143

Publication Information (EuropePMC)
Title Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease.
PubMed ID 33284643(Europe PMC)
doi 10.1161/circgen.120.003092
Publication Date Dec. 7, 2020
Journal Circ Genom Precis Med
Author(s) Fahed AC, Aragam KG, Hindy G, Chen YI, Chaudhary K, Dobbyn A, Krumholz HM, Sheu WHH, Rich SS, Rotter JI, Chowdhury R, Cho J, Do R, Ellinor PT, Kathiresan S, Khera AV.
Released in PGS Catalog: Feb. 23, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disease 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001746 PGS000013
(GPS_CAD)
 PSS000898|
African Ancestry|
16,755 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.25 [1.12, 1.4] — — PCs(1-4) —
PPM001747 PGS000013
(GPS_CAD)
 PSS000902|
South Asian Ancestry|
8,102 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.47 [1.36, 1.59] — — PCs(1-4) —
PPM001749 PGS000013
(GPS_CAD)
 PSS000901|
Hispanic or Latin American Ancestry|
9,085 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.52 [1.43, 1.62] — — PCs(1-4) —
PPM001745 PGS000013
(GPS_CAD)
 PSS000900|
European Ancestry|
474,498 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.6 [1.44, 1.78] — — PCs(1-4) —
PPM001748 PGS000013
(GPS_CAD)
 PSS000899|
East Asian Ancestry|
3,988 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.66 [1.47, 1.86] — — PCs(1-4) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000898 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 1,370 cases
  • , 15,385 controls
]
 — African unspecified — BioMe, MESA, PHB, UKB, VIRGO —
PSS000899 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 435 cases
  • , 3,553 controls
]
 — East Asian — TaiChi, UKB —
PSS000900 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 26,462 cases
  • , 448,036 controls
]
 — European — BioMe, MESA, PHB, UKB, VIRGO —
PSS000901 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 1,224 cases
  • , 7,861 controls
]
 — Hispanic or Latin American — BioMe, MESA, PHB, VIRGO —
PSS000902 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 874 cases
  • , 7,228 controls
]
 — South Asian — BRAVE, UKB —