PGS Publication: PGP000143

Publication Information (EuropePMC)
Title Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease.
PubMed ID 33284643(Europe PMC)
doi 10.1161/circgen.120.003092
Publication Date Dec. 7, 2020
Journal Circ Genom Precis Med
Author(s) Fahed AC, Aragam KG, Hindy G, Chen YI, Chaudhary K, Dobbyn A, Krumholz HM, Sheu WHH, Rich SS, Rotter...  JI, Chowdhury R, Cho J, Do R, Ellinor PT, Kathiresan S, Khera AV.Show more
Released in PGS Catalog: Feb. 23, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000013
(GPS_CAD)
PGP000006 |
Khera AV et al. Nat Genet (2018)
Coronary artery diseasecoronary artery disease6,630,150
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM001745PGS000013
(GPS_CAD)
PSS000900|
European Ancestry|
474,498 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		Reported Trait: Coronary artery diseaseOR: 1.6 [1.44, 1.78]——PCs(1-4)—
PPM001746PGS000013
(GPS_CAD)
PSS000898|
African Ancestry|
16,755 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		Reported Trait: Coronary artery diseaseOR: 1.25 [1.12, 1.4]——PCs(1-4)—
PPM001747PGS000013
(GPS_CAD)
PSS000902|
South Asian Ancestry|
8,102 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		Reported Trait: Coronary artery diseaseOR: 1.47 [1.36, 1.59]——PCs(1-4)—
PPM001748PGS000013
(GPS_CAD)
PSS000899|
East Asian Ancestry|
3,988 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		Reported Trait: Coronary artery diseaseOR: 1.66 [1.47, 1.86]——PCs(1-4)—
PPM001749PGS000013
(GPS_CAD)
PSS000901|
Hispanic or Latin American Ancestry|
9,085 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		Reported Trait: Coronary artery diseaseOR: 1.52 [1.43, 1.62]——PCs(1-4)—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000898Coronary artery disease was defined as myocardial infarction and/or history of coronary revasculariz... ation.Show more—
[
  • 1,370 cases
  • , 15,385 controls
]
—African unspecified—BioMe, MESA, PHB, UKB, VIRGO—
PSS000899Coronary artery disease was defined as myocardial infarction and/or history of coronary revasculariz... ation.Show more—
[
  • 435 cases
  • , 3,553 controls
]
—East Asian—TaiChi, UKB—
PSS000900Coronary artery disease was defined as myocardial infarction and/or history of coronary revasculariz... ation.Show more—
[
  • 26,462 cases
  • , 448,036 controls
]
—European—BioMe, MESA, PHB, UKB, VIRGO—
PSS000901Coronary artery disease was defined as myocardial infarction and/or history of coronary revasculariz... ation.Show more—
[
  • 1,224 cases
  • , 7,861 controls
]
—Hispanic or Latin American—BioMe, MESA, PHB, VIRGO—
PSS000902Coronary artery disease was defined as myocardial infarction and/or history of coronary revasculariz... ation.Show more—
[
  • 874 cases
  • , 7,228 controls
]
—South Asian—BRAVE, UKB—
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