PGS Publication: PGP000165

Publication Information (EuropePMC)
Title Self-reported hearing loss questions provide a good measure for genetic studies: a polygenic risk score analysis from UK Biobank.
PubMed ID 32203203(Europe PMC)
doi 10.1038/s41431-020-0603-2
Publication Date March 20, 2020
Journal Eur J Hum Genet
Author(s) Cherny SS, Livshits G, Wells HRR, Freidin MB, Malkin I, Dawson SJ, Williams FMK.
Released in PGS Catalog: April 28, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000762
(PRS_HD)
PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
Hearing difficultyage-related hearing impairment100,325
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000762/ScoringFiles/PGS000762.txt.gz
PGS000763
(PRS_HAID)
PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
Hearing aid useage-related hearing impairment4,270
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000763/ScoringFiles/PGS000763.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM001937PGS000763
(PRS_HAID)
PSS000971|
European Ancestry|
2,912 individuals
PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
Reported Trait: Hearing aid use——R²: 0.1923Age, sex—
PPM001938PGS000762
(PRS_HD)
PSS000972|
European Ancestry|
3,636 individuals
PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
Reported Trait: Hearing difficulties——R²: 0.0911Age, sex—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000971Hearing aid use cases responded ‘Yes’ to either ‘Do you wear a hearing aid?’ or ‘Wearing a hearing a... id’ while controls responded ‘No’.Show more—
[
  • 216 cases
  • , 2,696 controls
]
,
8.0 % Male samples
Mean = 59.32 years
Sd = 9.69 years		European
(British)		—TwinsUK—
PSS000972Hearing difficulty cases were defined as responding either ‘Yes, diagnosed by doctor or health profe... ssional’ or ‘Yes, not diagnosed by health professional’ to ‘Do you suffer from hearing loss?’ while participants that responded ‘No’ were assigned as controls.Show more—
[
  • 970 cases
  • , 2,666 controls
]
,
8.5 % Male samples
Mean = 60.34 years
Sd = 10.18 years		European
(British)		—TwinsUK—
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