PGS Publication: PGP000169

Publication Information (EuropePMC)
Title The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans.
PubMed ID 33605984(Europe PMC)
doi 10.1167/iovs.62.2.28
Publication Date Feb. 1, 2021
Journal Invest Ophthalmol Vis Sci
Author(s) Cole BS, Gudiseva HV, Pistilli M, Salowe R, McHugh CP, Zody MC, Chavali VRM, Ying GS, Moore JH, O'Brien JM.
Released in PGS Catalog: April 28, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000764
(PRS23_POAG)
 PGP000169 |
Cole BS et al. Invest Ophthalmol Vis Sci (2021)
 Primary-open angle glaucoma open-angle glaucoma 23
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000764/ScoringFiles/PGS000764.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001956 PGS000764
(PRS23_POAG)
 PSS000977|
Multi-ancestry (excluding European)|
3,830 individuals
 PGP000169 |
Cole BS et al. Invest Ophthalmol Vis Sci (2021)
 Reported Trait: Primary-open angle glaucoma — — Odds Ratio (OR per 1 point increase): 1.08 [1.06, 1.11] Age, ancestry (q0), gender —
PPM001957 PGS000764
(PRS23_POAG)
 PSS000978|
Multi-ancestry (excluding European)|
2,135 individuals
 PGP000169 |
Cole BS et al. Invest Ophthalmol Vis Sci (2021)
 Reported Trait: Primary-open angle glaucoma — — Odds Ratio (OR per 1 point increase): 1.08 [1.05, 1.12] Age, ancestry (q0), gender —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000977 Cases, classified by fellowship-trained glaucoma specialists were defined as having an open iridocorneal angle and characteristic optic nerve defects with corresponding visual field loss, whereas controls, classified by fellowship-trained glaucoma specialists exhibited a lack of confounding ocular conditions. —
[
  • 1,783 cases
  • , 2,047 controls
]
,
36.4 % Male samples
 — African American or Afro-Caribbean, African unspecified — POAAGG —
PSS000978 Cases, classified by fellowship-trained glaucoma specialists were defined as having an open iridocorneal angle and characteristic optic nerve defects with corresponding visual field loss, whereas controls, classified by fellowship-trained glaucoma specialists exhibited a lack of confounding ocular conditions. —
[
  • 755 cases
  • , 1,380 controls
]
 — African American or Afro-Caribbean, African unspecified — POAAGG —