PGS Publication: PGP000185

Publication Information (EuropePMC)
Title A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk.
PubMed ID 31792337(Europe PMC)
doi 10.1038/s41598-019-54701-1
Publication Date Dec. 2, 2019
Journal Sci Rep
Author(s) Adel Fahmideh M, Lavebratt C, Tettamanti G, Schüz J, Röösli M, Kjaerheim K, Grotzer MA, Johansen C, Kuehni CE, Lannering B, Schmidt LS, Darabi H, Feychting M.
Released in PGS Catalog: May 28, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000781
(GRS7_Glio)
 PGP000185 |
Adel Fahmideh M et al. Sci Rep (2019)
 Glioma brain neoplasm,
glioma		 5
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000781/ScoringFiles/PGS000781.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002036 PGS000781
(GRS7_Glio)
 PSS001009|
Multi-ancestry (including European)|
734 individuals
 PGP000185 |
Adel Fahmideh M et al. Sci Rep (2019)
 Reported Trait: Pediatric brain tumors OR: 1.25 [1.06, 1.49] — R²: 0.012 Age, sex, country —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001009 Cases include participants with the following tumors: Astrocytomas (ICCC-3 group IIIb), Other gliomas (ICCC-3 group IIId), Ependymomas (ICCC-3 group IIIa), Intracranial embryonal tumors (ICCC-3 group IIIc), other specified intracranial neoplasms (ICCC-3 group IIIe), unspecified intracranial neoplasms (ICCC-3 group IIIf) —
[
  • 245 cases
  • , 489 controls
]
,
54.09 % Male samples
 — European, NR European = 454, NR =280 CEFALO —