PGS Publication: PGP000194

Publication Information (EuropePMC)
Title Contribution of common risk variants to multiple sclerosis in Orkney and Shetland.
PubMed ID 34088990(Europe PMC)
doi 10.1038/s41431-021-00914-w
Publication Date June 4, 2021
Journal Eur J Hum Genet
Author(s) Barnes CLK, Hayward C, Porteous DJ, Campbell H, Joshi PK, Wilson JF.
Released in PGS Catalog: July 2, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000809
(PRS127_MS)
 PGP000194 |
Barnes CLK et al. Eur J Hum Genet (2021)
 Multiple sclerosis multiple sclerosis 127
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000809/ScoringFiles/PGS000809.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002137 PGS000809
(PRS127_MS)
 PSS001050|
European Ancestry|
725 individuals
 PGP000194 |
Barnes CLK et al. Eur J Hum Genet (2021)
 Reported Trait: Multiple sclerosis β: 0.6 AUROC: 0.705 (0.029) R²: 0.07 Age, sex, PCs(1-2) —
PPM002138 PGS000809
(PRS127_MS)
 PSS001051|
European Ancestry|
656 individuals
 PGP000194 |
Barnes CLK et al. Eur J Hum Genet (2021)
 Reported Trait: Multiple sclerosis β: 0.59 AUROC: 0.762 (0.055) R²: 0.075 Age, sex, PCs(1-2) —
PPM002139 PGS000809
(PRS127_MS)
 PSS001049|
European Ancestry|
8,370 individuals
 PGP000194 |
Barnes CLK et al. Eur J Hum Genet (2021)
 Reported Trait: Multiple Sclerosis β: 0.63 AUROC: 0.765 (0.042) R²: 0.069 Age, sex, PCs(1-2) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001049 Cases are individuals with multiple sclerosis. —
[
  • 29 cases
  • , 8,341 controls
]
 — European Mainland Scotland GS:SFHS —
PSS001050 Cases are individuals with multiple sclerosis. —
[
  • 80 cases
  • , 645 controls
]
 — European Orkney ORCADES —
PSS001051 Cases are individuals with multiple sclerosis. —
[
  • 14 cases
  • , 642 controls
]
 — European Shetlands VIKING —