PGS Publication: PGP000196

Publication Information (EuropePMC)
Title Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives.
PubMed ID 33532541(Europe PMC)
doi 10.1002/dad2.12142
Publication Date Jan. 22, 2021
Journal Alzheimers Dement (Amst)
Author(s) Najar J, van der Lee SJ, Joas E, Wetterberg H, Hardy J, Guerreiro R, Bras J, Waern M, Kern S, Zetter... berg H, Blennow K, Skoog I, Zettergren A.Show more
Released in PGS Catalog: July 2, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000811
(AD-PRS_39)
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Alzheimer's diseaseAlzheimer disease39
G
-
E
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000811/ScoringFiles/PGS000811.txt.gz
PGS000812
(AD-PRS_57)
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Alzheimer's diseaseAlzheimer disease57
G
-
E
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000812/ScoringFiles/PGS000812.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM002140PGS000811
(AD-PRS_39)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 non-carriersHR: 1.22 [1.1, 1.35]Age at blood sampling, birth year, sex, PCs(1-10)
PPM002141PGS000812
(AD-PRS_57)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementiaHR: 1.09 [1.01, 1.19]Age at blood sampling, birth year, sex, PCs(1-10)
PPM002142PGS000812
(AD-PRS_57)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 non-carriersHR: 1.15 [1.05, 1.27]Age at blood sampling, birth year, sex, PCs(1-10)
PPM002143PGS000811
(AD-PRS_39)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 non-carriers aged between 70 and 94HR: 1.16 [1.01, 1.34]Age at blood sampling, birth year, sex, PCs(1-10)
PPM002144PGS000811
(AD-PRS_39)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 non-carriers aged 95 years or aboveHR: 1.28 [1.1, 1.5]Age at blood sampling, birth year, sex, PCs(1-10)
PPM002145PGS000811
(AD-PRS_39)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 carriers aged 95 years or aboveHR: 0.62 [0.41, 0.95]Age at blood sampling, birth year, sex, PCs(1-10)
PPM002146PGS000812
(AD-PRS_57)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in individuals aged 95 or aboveHR: 1.15 [1.01, 1.32]Age at blood sampling, birth year, sex, PCs(1-10)
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS001052The diagnosis of dementia at each examination was based on Diagnostic and Statistical Manual of Ment... al Disorders Third Edition‐Revised (DSM‐III‐R) criteria, using information from neuropsychiatric examinations and close informant interviews. Dementia diagnoses for individuals lost to follow‐up were based on information obtained from the Swedish Inpatient Registry until 2012. Age of dementia onset was based on information provided by close informants, the examinations, and the Swedish Inpatient Register. If no information could be obtained from these sources, the age of onset was determined as the mid‐point between the last examination at which dementia criteria were not fulfilled and the first with a dementia diagnosis. Information on deaths during follow‐up was obtained from the Swedish Population Registry until December 31, 2016. Of the 605 dementia cases, 182 were carriers of an APOE ɛ4 allele.Show moreMean = 7.2 years
Sd = 4.7 years
[
  • 605 cases
  • , 1,447 controls
]
EuropeanNRGothenburg H70 Birth Cohort studies
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