PGS Publication: PGP000202

Publication Information (EuropePMC)
Title Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study.
PubMed ID 34082474(Europe PMC)
doi 10.1002/gepi.22389
Publication Date June 3, 2021
Journal Genet Epidemiol
Author(s) Bauer A, Zierer A, Gieger C, Büyüközkan M, Müller-Nurasyid M, Grallert H, Meisinger C, Strauch K, Pr... okisch H, Roden M, Peters A, Krumsiek J, Herder C, Koenig W, Thorand B, Huth C.Show more
Released in PGS Catalog: July 29, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000818
(GRS_Metabo)
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
Coronary heart diseasecoronary artery disease138
G
-
E
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000818/ScoringFiles/PGS000818.txt.gz
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External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000013
(GPS_CAD)
PGP000006 |
Khera AV et al. Nat Genet (2018)
Coronary artery diseasecoronary artery disease6,630,150
G
D
E
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM002178PGS000818
(GRS_Metabo)
PSS001063|
European Ancestry|
2,909 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
Reported Trait: Incident coronary heart diseaseC-index: 0.7571 [0.7234, 0.7908]Age, sex, survey
PPM002179PGS000818
(GRS_Metabo)
PSS001063|
European Ancestry|
2,909 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
Reported Trait: Incident coronary heart diseaseC-index: 0.792 [0.7622, 0.8219]Age, sex, survey, Framingham risk score (diabetes status, current and former smoking status, systoli... c blood pressure, antihypertensive medication, HDL cholesterol, total cholesterol)Show more
PPM002180PGS000818
(GRS_Metabo)
PSS001064|
European Ancestry|
1,939 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
Reported Trait: Incident coronary heart diseaseHR: 1.2341 [1.1137, 1.3676]
PPM002181PGS000818
(GRS_Metabo)
PSS001064|
European Ancestry|
1,939 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
Reported Trait: Incident coronary heart diseaseHR: 1.2126 [1.0766, 1.3659]Age, sex, survey
PPM002182PGS000013
(GPS_CAD)
PSS001063|
European Ancestry|
2,909 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
|Ext.
Reported Trait: Incident coronary heart diseaseC-index: 0.573 [0.5254, 0.6212]Only 6,481,934 SNPs from PGS000013 were utilised. SNPs were not included due to imputation quality R... ^2 < 0.3Show more
PPM002183PGS000013
(GPS_CAD)
PSS001063|
European Ancestry|
2,909 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
|Ext.
Reported Trait: Incident coronary heart diseaseC-index: 0.7752 [0.7443, 0.8029]Age, sex, surveyOnly 6,481,934 SNPs from PGS000013 were utilised. SNPs were not included due to imputation quality R... ^2 < 0.3Show more
PPM002184PGS000013
(GPS_CAD)
PSS001063|
European Ancestry|
2,909 individuals
PGP000202 |
Bauer A et al. Genet Epidemiol (2021)
|Ext.
Reported Trait: Incident coronary heart diseaseC-index: 0.8012 [0.7775, 0.8353]Age, sex, survey, Framingham risk score (diabetes status, current and former smoking status, systoli... c blood pressure, antihypertensive medication, HDL cholesterol, total cholesterol)Show moreOnly 6,481,934 SNPs from PGS000013 were utilised. SNPs were not included due to imputation quality R... ^2 < 0.3Show more
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS001063Cases were individuals with incident coronary heart disesase (CHD). The outcome CHD was a combined e... ndpoint of nonfatal myocardial infarction as well as coronary death and sudden death (International Classification of Disease 9th Revision: 410–414 and 798). Until December 2000, the diagnosis of a major, nonfatal myocardial infarction and coronary death was based on the MONICA algorithm in which a diagnosis of a major CHD event was based on symptoms, cardiac enzymes (creatine kinase, aspartate aminotransferase, and lactate dehydrogenase), serial changes from 12‐lead electrocardiograms (ECGs) evaluated by Minnesota coding, necropsy results and history of CHD in fatal cases. Since January 1, 2001, the diagnosis of myocardial infarction was based on the European Society of Cardiology and American College of Cardiology criteria. Incident events were identified through follow‐up questionnaires or through the MONICA/KORA myocardial infarction registry, which monitors the occurrence of all in‐ and out of‐hospital fatal and nonfatal myocardial infarctions among the 25–74‐year‐old inhabitants of the study region. Initially identified self‐reported incident cases and the self‐reported date of diagnosis not covered by the MONICA/KORA myocardial infarction registry, were validated by hospital records or by contacting the patient's treating physician. Deaths from myocardial in- farction were validated by death certificates, autopsy reports, chart reviews, or information from the last treating physician.Show moreMedian = 14.0 years
IQR = [14.0, 14.0] years
[
  • 160 cases
  • , 2,749 controls
]
,
48.1 % Male samples
EuropeanKORA
PSS001064Cases were individuals with incident coronary heart disesase (CHD). The outcome CHD was a combined e... ndpoint of nonfatal myocardial infarction as well as coronary death and sudden death (International Classification of Disease 9th Revision: 410–414 and 798). Until December 2000, the diagnosis of a major, nonfatal myocardial infarction and coronary death was based on the MONICA algorithm in which a diagnosis of a major CHD event was based on symptoms, cardiac enzymes (creatine kinase, aspartate aminotransferase, and lactate dehydrogenase), serial changes from 12‐lead electrocardiograms (ECGs) evaluated by Minnesota coding, necropsy results and history of CHD in fatal cases. Since January 1, 2001, the diagnosis of myocardial infarction was based on the European Society of Cardiology and American College of Cardiology criteria. Incident events were identified through follow‐up questionnaires or through the MONICA/KORA myocardial infarction registry, which monitors the occurrence of all in‐ and out of‐hospital fatal and nonfatal myocardial infarctions among the 25–74‐year‐old inhabitants of the study region. Initially identified self‐reported incident cases and the self‐reported date of diagnosis not covered by the MONICA/KORA myocardial infarction registry, were validated by hospital records or by contacting the patient's treating physician. Deaths from myocardial in- farction were validated by death certificates, autopsy reports, chart reviews, or information from the last treating physician.Show moreMedian = 14.0 years
IQR = [10.3, 14.0] years
[
  • 451 cases
  • , 1,488 controls
]
,
53.06 % Male samples
EuropeanKORA
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