| Publication Information (EuropePMC) | |
| Title | The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study. |
| PubMed ID | 29555425(Europe PMC) |
| doi | 10.1016/s1474-4422(18)30053-x |
| Publication Date | March 16, 2018 |
| Journal | Lancet Neurol |
| Author(s) | van der Lee SJ, Wolters FJ, Ikram MK, Hofman A, Ikram MA, Amin N, van Duijn CM. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000823 (GRS23_AD) |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Alzheimer's disease | Alzheimer disease | 23 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000823/ScoringFiles/PGS000823.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM002216 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident dementia at age 85 in individuals homozygous for APOE ε4 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 0.00022 | Mortality | — |
| PPM002218 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident dementia at age 90 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 5.20e-13 | Mortality | — |
| PPM002215 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident Alzheimer's disease at age 80 in individuals homozygous for APOE ε4 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 0.0056 | Non-Alzheimer's disease dementia, mortality | — |
| PPM002217 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident Alzheimer's disease at age 85 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 7.90e-14 | Non-Alzheimer's disease dementia, mortality | — |
| PPM002214 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident Alzheimer's disease at age 85 in individuals homozygous for APOE ε4 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 0.0085 | Non-Alzheimer's disease dementia, mortality | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS001080 | Cases included incident Alzheimer's disease (AD) and other types of incident dementia. Of the 1,609 dementia cases, 1,262 were individuals with AD and 347 were individuals with other types of dementia excluding AD. A consensus panel led by a consultant neurologist established the final diagnosis according to standard criteria for dementia (Diagnostic and Statistical Manual of Mental Disorders III-revised) and Alzheimer’s disease (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association). Of the total 12,255 individuals, APOE genotypes were available for 11,375. From those genotyped, 261 individuals were homozygous for APOE ε4 (ε4/ε4). Of the 261 ε4/ε4 individuals, 72 had AD whilst 11 had other types of dementia excluding AD. | Median = 10.9 years | [ ,
41.5 % Male samples |
European (Dutch) |
— | RS | — |