PGS Publication: PGP000218

Publication Information (EuropePMC)
Title Comparisons of Polyexposure, Polygenic, and Clinical Risk Scores in Risk Prediction of Type 2 Diabetes.
PubMed ID 33563654(Europe PMC)
doi 10.2337/dc20-2049
Publication Date Feb. 9, 2021
Journal Diabetes Care
Author(s) He Y, Lakhani CM, Rasooly D, Manrai AK, Tzoulaki I, Patel CJ.
Released in PGS Catalog: Aug. 26, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000014
(GPS_T2D)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 6,917,436
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000014/ScoringFiles/PGS000014.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002477 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes — C-index: 0.709 [0.696, 0.722] Hazard ratio (HR, top 10% vs. remaining 90%): 2.0 [1.73, 2.31] Sex, age, principal components, assessment center —
PPM002478 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes in males — C-index: 0.68 [0.663, 0.697] — Age, principal components and assessment center —
PPM002479 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes in females — C-index: 0.705 [0.682, 0.728] — Age, principal components and assessment center —
PPM002480 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes — C-index: 0.776 [0.764, 0.788] — Sex, age, principal components, assessment center, polyexposure score —
PPM002481 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes — C-index: 0.844 [0.834, 0.854] — Sex, age, principal components, assessment center, clinical risk score —
PPM002482 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes — C-index: 0.855 [0.845, 0.865] — Sex, age, principal components, assessment center, polyexposure socre, clinical risk score —
PPM002483 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes in females — C-index: 0.786 [0.765, 0.807] — Age, principal components, assessment center, polyexposure score —
PPM002485 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes in females — C-index: 0.859 [0.842, 0.876] — Sex, age, principal components, assessment center, clinical risk score —
PPM002486 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes in males — C-index: 0.749 [0.734, 0.764] — Age, principal components, assessment center, polyexposure score —
PPM002487 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes in males — C-index: 0.821 [0.808, 0.834] — Age, principal components, assessment center, polyexposure socre, clinical risk score —
PPM002488 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes in males — C-index: 0.834 [0.821, 0.847] — Sex, age, principal components, assessment center, clinical risk score —
PPM002484 PGS000014
(GPS_T2D)
 PSS001117|
European Ancestry|
68,229 individuals
 PGP000218 |
He Y et al. Diabetes Care (2021)
|Ext.		 Reported Trait: Incident type II diabetes in females — C-index: 0.869 [0.853, 0.885] — Age, principal components, assessment center, polyexposure socre, clinical risk score —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001117 T2D cases were defined as having an ICD-10 code of E11.X or having self-reported T2D in the in- terview. Only cases in which the individuals did not have T2D during the first assessment visit period (2006–2010) but were subsequently fol- lowed up for incident T2D events were considered. Median = 3.58 years
[
  • 1,281 cases
  • , 66,948 controls
]
,
47.81 % Male samples
 — European — UKB —