| Publication Information (EuropePMC) | |
| Title | Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis. |
| PubMed ID | 29674426(Europe PMC) |
| doi | 10.1182/blood-2017-11-814608 |
| Publication Date | April 19, 2018 |
| Journal | Blood |
| Author(s) | Kleinstern G, Camp NJ, Goldin LR, Vachon CM, Vajdic CM, de Sanjose S, Weinberg JB, Benavente Y, Casabonne D, Liebow M, Nieters A, Hjalgrim H, Melbye M, Glimelius B, Adami HO, Boffetta P, Brennan P, Maynadie M, McKay J, Cocco PL, Shanafelt TD, Call TG, Norman AD, Hanson C, Robinson D, Chaffee KG, Brooks-Wilson AR, Monnereau A, Clavel J, Glenn M, Curtin K, Conde L, Bracci PM, Morton LM, Cozen W, Severson RK, Chanock SJ, Spinelli JJ, Johnston JB, Rothman N, Skibola CF, Leis JF, Kay NE, Smedby KE, Berndt SI, Cerhan JR, Caporaso N, Slager SL. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000874 (PRS41_CLL) |
PGP000220 | Kleinstern G et al. Blood (2018) |
Chronic lymphocytic leukemia | chronic lymphocytic leukemia | 41 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000874/ScoringFiles/PGS000874.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM002493 | PGS000874 (PRS41_CLL) |
PSS001123| Multi-ancestry (including European)| 3,958 individuals |
PGP000220 | Kleinstern G et al. Blood (2018) |
Reported Trait: Chronic lymphocytic leukemia | OR: 2.49 [2.28, 2.8] | C-index: 0.79 [0.78, 0.8] | — | Age, sex, study, socioeconomic status (when available) | Odds Ratio (OR, top 20% vs middle 20%) = 3.64 [2.94 - 4.51] |
| PPM002494 | PGS000874 (PRS41_CLL) |
PSS001123| Multi-ancestry (including European)| 3,958 individuals |
PGP000220 | Kleinstern G et al. Blood (2018) |
Reported Trait: Chronic lymphocytic leukemia in individuals with no family history of hematological cancers | OR: 2.46 [2.19, 2.76] | C-index: 0.791 [0.77, 0.81] | — | Age, sex, study, socioeconomic status (when available) | Odds Ratio (OR, top 20% vs middle 20%) = 3.29 [2.49 - 4.35] |
| PPM002495 | PGS000874 (PRS41_CLL) |
PSS001123| Multi-ancestry (including European)| 3,958 individuals |
PGP000220 | Kleinstern G et al. Blood (2018) |
Reported Trait: Chronic lymphocytic leukemia in individuals with a family history of hematological cancers | OR: 3.79 [2.44, 5.87] | C-index: 0.861 [0.82, 0.9] | — | Age, sex, study, socioeconomic status (when available) | Odds Ratio (OR, top 20% vs middle 20%) = 7.58 [2.74 - 21.0] |
| PPM002496 | PGS000874 (PRS41_CLL) |
PSS001121| Ancestry Not Reported| 218 individuals |
PGP000220 | Kleinstern G et al. Blood (2018) |
Reported Trait: Chronic lymphocytic leukemia | OR: 2.44 [1.65, 3.62] | C-index: 0.798 [0.74, 0.85] | — | Age, sex, study, socioeconomic status (when available) | Odds Ratio (OR, top 20% vs middle 20%) = 3.51 [1.39 - 8.86] |
| PPM002497 | PGS000874 (PRS41_CLL) |
PSS001122| Ancestry Not Reported| 153 individuals |
PGP000220 | Kleinstern G et al. Blood (2018) |
Reported Trait: Monoclonal B-cell lymphocytosis | OR: 2.3 [1.44, 3.67] | C-index: 0.773 [0.7, 0.85] | — | Age, sex, study, socioeconomic status (when available) | Odds Ratio (OR, top 20% vs middle 20%) = 4.36 [1.45 - 13.1] |
| PPM002498 | PGS000874 (PRS41_CLL) |
PSS001119| Ancestry Not Reported| 1,468 individuals |
PGP000220 | Kleinstern G et al. Blood (2018) |
Reported Trait: Chronic lymphocytic leukemia | OR: 3.02 [2.49, 3.65] | C-index: 0.779 [0.74, 0.81] | — | Age, sex | Odds Ratio (OR, top 20% vs middle 20%) = 4.47 [2.76 - 7.24] |
| PPM002499 | PGS000874 (PRS41_CLL) |
PSS001120| Ancestry Not Reported| 1,362 individuals |
PGP000220 | Kleinstern G et al. Blood (2018) |
Reported Trait: Monoclonal B-cell lymphocytosis | OR: 2.81 [2.18, 3.61] | C-index: 0.774 [0.73, 0.82] | — | Age, sex | Odds Ratio (OR, top 20% vs middle 20%) = 4.34 [2.21 - 8.50] |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS001119 | Cases were individuals with chronic lymphocytic leukemia. | — | [
|
— | Not reported | — | MAYO | Cases were obtained from the Genetic Epidemiology of CLL (GEC) Consortium |
| PSS001120 | Cases were individuals with monoclonal B-cell lymphocytosis. | — | [
|
— | Not reported | — | MAYO | Cases were obtained from the Genetic Epidemiology of CLL (GEC) Consortium |
| PSS001121 | Cases were individuals with chronic lymphocytic leukemia. | — | [
|
— | Not reported | — | NR | Cases and controls were obtained from the Genetic Epidemiology of CLL (GEC) Consortium |
| PSS001122 | Cases were individuals with monoclonal B-cell lymphocytosis. | — | [
|
— | Not reported | — | NR | Cases and controls were obtained from the Genetic Epidemiology of CLL (GEC) Consortium |
| PSS001123 | Cases were individuals with chronic lymphocytic leukemia (CLL). Of the 3,958 individuals, 242 had a family history (FH) of hematological cancers, whereas 2,409 had no FH of hematological cancers. Of the 242 individuals with a FH, 112 had CLL. Of the 2,409 without a FH, 783 had CLL. FH was defined as a person self-reporting any hematological maligcancy among first-degree relatives. Hematological malignancies were defined as any non-Hodgkin lymphoma, Hodgkin lymphoma, multiple myeloma, or leukemia. | — | [ ,
60.81 % Male samples |
— | European, NR | — | 8 cohorts
|
Possible significant sample overlap between this dataset and the dataset used to source PRS41_CLL. |