Publication Information (EuropePMC) | |
Title | Risk of dementia in <i>APOE</i> ε4 carriers is mitigated by a polygenic risk score. |
PubMed ID | 34541285(Europe PMC) |
doi | 10.1002/dad2.12229 |
Publication Date | Sept. 14, 2021 |
Journal | Alzheimers Dement (Amst) |
Author(s) | Ebenau JL, van der Lee SJ, Hulsman M, Tesi N, Jansen IE, Verberk IMW, van Leeuwenstijn M, Teunissen ... CE, Barkhof F, Prins ND, Scheltens P, Holstege H, van Berckel BNM, van der Flier WM.Show more |
Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS001775 (PRS39_AD) |
PGP000255 | Ebenau JL et al. Alzheimers Dement (Amst) (2021) |
Alzheimer's disease | Alzheimer disease | 39 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001775/ScoringFiles/PGS001775.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM009238 | PGS001775 (PRS39_AD) |
PSS007663| European Ancestry| 532 individuals |
PGP000255 | Ebenau JL et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Other dementia (excluding all-type dementia and Alzheimer's disease) | HR: 0.5 [0.3, 0.9] | — | — | Age, sex, population substructure, Mini-Mental State Examination (predictor: APOE ε4 allele or norma... lized PRS, outcome: clinical progression to dementia)Show more | — |
PPM009237 | PGS001775 (PRS39_AD) |
PSS007663| European Ancestry| 532 individuals |
PGP000255 | Ebenau JL et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Alzheimer's disease dementia | HR: 1.7 [1.1, 2.8] | — | — | Age, sex, population substructure, Mini-Mental State Examination (predictor: APOE ε4 allele or norma... lized PRS, outcome: clinical progression to dementia)Show more | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS007663 | Cases were individuals with dementia. Of the 82 cases with dementia, 41 had all-type dementia, 25 ha... d Alzheimer's disease (AD) dementia and 16 had other types of dementia.Show more | — | [
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— | European | — | AmDem, SCIENCe | — |