PGS Publication: PGP000259

Publication Information (EuropePMC)
Title Combination of a 15-SNP Polygenic Risk Score and Classical Risk Factors for the Prediction of Breast Cancer Risk in Cypriot Women.
PubMed ID 34572793(Europe PMC)
doi 10.3390/cancers13184568
Publication Date Sept. 11, 2021
Journal Cancers (Basel)
Author(s) Yiangou K, Kyriacou K, Kakouri E, Marcou Y, Panayiotidis MI, Loizidou MA, Hadjisavvas A, Michailidou K.
Released in PGS Catalog: Nov. 25, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001778
(PRS15_BC)
 PGP000259 |
Yiangou K et al. Cancers (Basel) (2021)
 Breast cancer breast carcinoma 15
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001778/ScoringFiles/PGS001778.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009262 PGS001778
(PRS15_BC)
 PSS007670|
European Ancestry|
1,780 individuals
 PGP000259 |
Yiangou K et al. Cancers (Basel) (2021)
 Reported Trait: Breast cancer OR: 1.66 [1.25, 2.2] AUROC: 0.548 — Age —
PPM009264 PGS001778
(PRS15_BC)
 PSS007670|
European Ancestry|
1,780 individuals
 PGP000259 |
Yiangou K et al. Cancers (Basel) (2021)
 Reported Trait: Breast cancer OR: 1.57 [1.18, 2.08] AUROC: 0.578 — Age, family history —
PPM009261 PGS001778
(PRS15_BC)
 PSS007670|
European Ancestry|
1,780 individuals
 PGP000259 |
Yiangou K et al. Cancers (Basel) (2021)
 Reported Trait: Breast cancer OR: 1.66 [1.25, 2.19] AUROC: 0.547 [0.52, 0.57] — — —
PPM009263 PGS001778
(PRS15_BC)
 PSS007670|
European Ancestry|
1,780 individuals
 PGP000259 |
Yiangou K et al. Cancers (Basel) (2021)
 Reported Trait: Breast cancer OR: 1.56 [1.18, 2.08] AUROC: 0.578 — Family history —
PPM009265 PGS001778
(PRS15_BC)
 PSS007670|
European Ancestry|
1,780 individuals
 PGP000259 |
Yiangou K et al. Cancers (Basel) (2021)
 Reported Trait: Breast cancer — AUROC: 0.6975 [0.673, 0.722] Odds Ratio (OR, top 10% vs middle10%): 4.58 [2.88, 7.4] Age at interview, menopausal status, age at menarche, age at first full-term pregnancy(1-4), parous, breast feeding, smoking status, body mass index, height, hormone-replacement therapy ever use, family history —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007670 Cases were individuals who had been diagnosed with breast cancer. —
[
  • 880 cases
  • , 900 controls
]
,
0.0 % Male samples
 — European
(Greek-Cypriot)		 — NR Cases and controls were obtained from the MASTOS study.