PGS Publication: PGP000267

Publication Information (EuropePMC)
Title Prediction of primary venous thromboembolism based on clinical and genetic factors within the U.K. Biobank.
PubMed ID 34725413(Europe PMC)
doi 10.1038/s41598-021-00796-4
Publication Date Nov. 1, 2021
Journal Sci Rep
Author(s) Kolin DA, Kulm S, Elemento O.
Released in PGS Catalog: Dec. 10, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002235
(elasticnet_VTE)
 PGP000267 |
Kolin DA et al. Sci Rep (2021)
 Venous thromboembolism venous thromboembolism 36
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002235/ScoringFiles/PGS002235.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012709 PGS002235
(elasticnet_VTE)
 PSS009500|
European Ancestry|
269,164 individuals
 PGP000267 |
Kolin DA et al. Sci Rep (2021)
 Reported Trait: Incident venous thromboembolism — — Odds Ratio (OR, top 1% vs bottom 99%): 5.37 [5.34, 5.4] — —
PPM012710 PGS002235
(elasticnet_VTE)
 PSS009500|
European Ancestry|
269,164 individuals
 PGP000267 |
Kolin DA et al. Sci Rep (2021)
 Reported Trait: Incident venous thromboembolism — — Subhazard ratio (SHR, top 20.2% vs bottom 79.8%): 3.02 [2.63, 3.47] — —
PPM012711 PGS002235
(elasticnet_VTE)
 PSS009500|
European Ancestry|
269,164 individuals
 PGP000267 |
Kolin DA et al. Sci Rep (2021)
 Reported Trait: Incident venous thromboembolism — — Subhazard ratio (SHR, top 20.2% vs bottom 79.8%): 7.51 [6.28, 8.98] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009500 — —
[
  • 2,295 cases
  • , 266,869 controls
]
 — European
(British)		 — UKB —