PGS Publication: PGP000278

Publication Information (EuropePMC)
Title Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank.
PubMed ID 35016652(Europe PMC)
doi 10.1186/s12916-021-02198-9
Publication Date Jan. 12, 2022
Journal BMC Med
Author(s) Dashti HS, Miranda N, Cade BE, Huang T, Redline S, Karlson EW, Saxena R.
Released in PGS Catalog: Jan. 24, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002251
(PRS97_BMI)
 PGP000278 |
Dashti HS et al. BMC Med (2022)
 Body mass index (BMI) body mass index 97
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002251/ScoringFiles/PGS002251.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012804 PGS002251
(PRS97_BMI)
 PSS009565|
European Ancestry|
33,511 individuals
 PGP000278 |
Dashti HS et al. BMC Med (2022)
 Reported Trait: Body mass index β: 0.83 [0.76, 0.9] — — age, sex, genotyping array, and 5 PCs of ancestry beta unit kg/m2

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009565 Clinically measured BMI — 33,511 individuals,
46.9 % Male samples
 Mean = 60.2 years
Sd = 16.9 years		 European — MGBB —