PGS Publication: PGP000285

Publication Information (EuropePMC)
Title Development and Validation of a Polygenic Risk Score for Stroke in the Chinese Population.
PubMed ID 34031205(Europe PMC)
doi 10.1212/wnl.0000000000012263
Publication Date May 24, 2021
Journal Neurology
Author(s) Lu X, Niu X, Shen C, Liu F, Liu Z, Huang K, Wang L, Li J, Hu D, Zhao Y, Yang X, Lu F, Liu X, Cao J, Chen S, Li H, Tang W, Ren Z, Yu L, Wu X, Wu X, Li Y, Zhang H, Huang J, Hu Z, Shen H, Willer CJ, Gu D.
Released in PGS Catalog: Feb. 23, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002259
(metaPRS_Stroke)
 PGP000285 |
Lu X et al. Neurology (2021)
 Stroke stroke 534
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002259/ScoringFiles/PGS002259.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012867 PGS002259
(metaPRS_Stroke)
 PSS009585|
East Asian Ancestry|
41,006 individuals
 PGP000285 |
Lu X et al. Neurology (2021)
 Reported Trait: Incident stroke HR: 1.28 [1.21, 1.36] — Hazard Ratio (HR, highest vs lowest quintile): 1.99 [1.66, 2.38] Sex —
PPM012868 PGS002259
(metaPRS_Stroke)
 PSS009585|
East Asian Ancestry|
41,006 individuals
 PGP000285 |
Lu X et al. Neurology (2021)
 Reported Trait: Incident ischemic stroke HR: 1.29 [1.2, 1.39] — Hazard Ratio (HR, highest vs lowest quintile): 2.13 [1.69, 2.69] Sex —
PPM012869 PGS002259
(metaPRS_Stroke)
 PSS009585|
East Asian Ancestry|
41,006 individuals
 PGP000285 |
Lu X et al. Neurology (2021)
 Reported Trait: Incident hemorrhagic stroke HR: 1.3 [1.17, 1.45] — Hazard Ratio (HR, highest vs lowest quintile): 1.98 [1.41, 2.77] Sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009585 Incident stroke as a confirmed diagnosis of first-ever fatal or nonfatal stroke event during follow-up (I60-I69) — 41,006 individuals,
43.1 % Male samples
 Mean = 51.9 years East Asian — NR —