| Publication Information (EuropePMC) | |
| Title | A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study. |
| PubMed ID | 35195259(Europe PMC) |
| doi | 10.1093/eurheartj/ehac093 |
| Publication Date | Feb. 23, 2022 |
| Journal | Eur Heart J |
| Author(s) | Lu X, Liu Z, Cui Q, Liu F, Li J, Niu X, Shen C, Hu D, Huang K, Chen J, Xing X, Zhao Y, Lu F, Liu X, ... Cao J, Chen S, Ma H, Yu L, Wu X, Wu X, Li Y, Zhang H, Mo X, Zhao L, Huang J, Wang L, Wen W, Shu XO, Takeuchi F, Koh WP, Tai ES, Cheng CY, Wong TY, Chang X, Chan MY, Gao W, Zheng H, Chen K, Chen J, He J, Tang CS, Lam KSL, Tse HF, Cheung CYY, Takahashi A, Kubo M, Kato N, Terao C, Kamatani Y, Sham PC, Heng CK, Hu Z, Chen YE, Wu T, Shen H, Willer CJ, Gu D.Show more |
Polygenic Score ID & Name
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PGS Publication ID (PGP)
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Reported Trait
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Mapped Trait(s) (Ontology)
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Number of Variants
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Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link)
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|---|---|---|---|---|---|---|
| PGS002262 (metaPRS_CAD) | PGP000289 | Lu X et al. Eur Heart J (2022) | Coronary artery disease | coronary artery disease | 540 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002262/ScoringFiles/PGS002262.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score
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PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM012875 | PGS002262 (metaPRS_CAD) | PSS009589| East Asian Ancestry| 41,271 individuals | PGP000289 | Lu X et al. Eur Heart J (2022) | Reported Trait: Incident coronary artery disease | HR: 1.44 [1.36, 1.52] | C-index: 0.615 [0.598, 0.631] | — | — | — |
| PPM012876 | PGS002262 (metaPRS_CAD) | PSS009589| East Asian Ancestry| 41,271 individuals | PGP000289 | Lu X et al. Eur Heart J (2022) | Reported Trait: Incident coronary artery disease | — | — | Hazard Ratio (HR, highest vs lowest quintile): 2.91 [2.43, 3.49] | — | — |
| PPM012877 | PGS002262 (metaPRS_CAD) | PSS009589| East Asian Ancestry| 41,271 individuals | PGP000289 | Lu X et al. Eur Heart J (2022) | Reported Trait: Incident coronary artery disease (men) | — | — | Hazard Ratio (HR, highest vs lowest quintile): 3.88 [2.94, 5.13] | sex and first 4 PCs | — |
| PPM012878 | PGS002262 (metaPRS_CAD) | PSS009589| East Asian Ancestry| 41,271 individuals | PGP000289 | Lu X et al. Eur Heart J (2022) | Reported Trait: Incident coronary artery disease (women) | — | — | Hazard Ratio (HR, highest vs lowest quintile): 2.27 [1.78, 2.9] | sex and first 4 PCs | — |
| PPM012879 | PGS002262 (metaPRS_CAD) | PSS009589| East Asian Ancestry| 41,271 individuals | PGP000289 | Lu X et al. Eur Heart J (2022) | Reported Trait: Coronary artery disease | — | — | Hazard Ratio (HR, highest vs lowest quintile): 5.66 [3.98, 8.04] | sex, first 4 PCs and CAD family history | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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|---|---|---|---|---|---|---|---|---|
| PSS009589 | — | Mean = 13.0 years | [ ,
42.5 % Male samples | Mean = 52.3 years Sd = 10.6 years | East Asian | — | CIMIC, ChinaMUCA-1998, InterASIA | — |