PGS Publication: PGP000290

Publication Information (EuropePMC)
Title Prediction of Major Adverse Cardiovascular Events From Retinal, Clinical, and Genomic Data in Individuals With Type 2 Diabetes: A Population Cohort Study.
PubMed ID 35043139(Europe PMC)
doi 10.2337/dc21-1124
Publication Date March 1, 2022
Journal Diabetes Care
Author(s) Mordi IR, Trucco E, Syed MG, MacGillivray T, Nar A, Huang Y, George G, Hogg S, Radha V, Prathiba V, Anjana RM, Mohan V, Palmer CNA, Pearson ER, Lang CC, Doney ASF.
Released in PGS Catalog: March 16, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disease 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012880 PGS000013
(GPS_CAD)
 PSS009590|
Multi-ancestry (including European)|
5,152 individuals
 PGP000290 |
Mordi IR et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Incident major adverse cardiovascular events in type 2 diabetes HR: 1.68 [1.49, 1.9] — — Age, sex, glycated hemoglobin, duration of diabetes, retinal risk score, and PCE —
PPM012881 PGS000013
(GPS_CAD)
 PSS009590|
Multi-ancestry (including European)|
5,152 individuals
 PGP000290 |
Mordi IR et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Incident major adverse cardiovascular events in type 2 diabetes — AUROC: 0.686 [0.667, 0.704] — Retinal risk score, age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009590 individuals with type 2 diabetes. Events consist of 794 CV deaths (15.4%), 274 non-fatal MI (5.3%) and 151 non-fatal stroke (2.9%) Median = 9.8 years
[
  • 1,017 cases
  • , 4,135 controls
]
,
56.1 % Male samples
 Mean = 65.2 years European, NR — GoDARTS —