PGS Publication: PGP000290

Publication Information (EuropePMC)
Title Prediction of Major Adverse Cardiovascular Events From Retinal, Clinical, and Genomic Data in Individuals With Type 2 Diabetes: A Population Cohort Study.
PubMed ID 35043139(Europe PMC)
doi 10.2337/dc21-1124
Publication Date March 1, 2022
Journal Diabetes Care
Author(s) Mordi IR, Trucco E, Syed MG, MacGillivray T, Nar A, Huang Y, George G, Hogg S, Radha V, Prathiba V, ... Anjana RM, Mohan V, Palmer CNA, Pearson ER, Lang CC, Doney ASF.Show more
Released in PGS Catalog: March 16, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000013
(GPS_CAD)
PGP000006 |
Khera AV et al. Nat Genet (2018)
Coronary artery diseasecoronary artery disease6,630,150
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM012880PGS000013
(GPS_CAD)
PSS009590|
Multi-ancestry (including European)|
5,152 individuals
PGP000290 |
Mordi IR et al. Diabetes Care (2022)
|Ext.		Reported Trait: Incident major adverse cardiovascular events in type 2 diabetesHR: 1.68 [1.49, 1.9]——Age, sex, glycated hemoglobin, duration of diabetes, retinal risk score, and PCE—
PPM012881PGS000013
(GPS_CAD)
PSS009590|
Multi-ancestry (including European)|
5,152 individuals
PGP000290 |
Mordi IR et al. Diabetes Care (2022)
|Ext.		Reported Trait: Incident major adverse cardiovascular events in type 2 diabetes—AUROC: 0.686 [0.667, 0.704]—Retinal risk score, age, sex—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS009590individuals with type 2 diabetes. Events consist of 794 CV deaths (15.4%), 274 non-fatal MI (5.3%) a... nd 151 non-fatal stroke (2.9%)Show moreMedian = 9.8 years
[
  • 1,017 cases
  • , 4,135 controls
]
,
56.1 % Male samples
Mean = 65.2 yearsEuropean, NR—GoDARTS—
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