PGS Publication: PGP000298

Publication Information (EuropePMC)
Title Prediction of clinically significant prostate cancer using polygenic risk models in Asians.
PubMed ID 34983122(Europe PMC)
doi 10.4111/icu.20210305
Publication Date Jan. 1, 2022
Journal Investig Clin Urol
Author(s) Song SH, Kim E, Woo E, Kwon E, Yoon S, Kim JK, Lee H, Oh JJ, Lee S, Hong SK, Byun SS.
Released in PGS Catalog: April 1, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002268
(PRS_csPCa)
 PGP000298 |
Song SH et al. Investig Clin Urol (2022)
 Prostate cancer prostate carcinoma 29
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002268/ScoringFiles/PGS002268.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012919 PGS002268
(PRS_csPCa)
 PSS009617|
East Asian Ancestry|
1,133 individuals
 PGP000298 |
Song SH et al. Investig Clin Urol (2022)
 Reported Trait: Clinically significant prostate cancer — AUROC: 0.7 [0.667, 0.734] OR (very high vs moderate group): 4.92 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009617 — —
[
  • 311 cases
  • , 822 controls
]
,
100.0 % Male samples
 — East Asian
(Korean)		 — NR —