PGS Publication: PGP000318

Publication Information (EuropePMC)
Title Genetic risk score for plasma uric acid levels is associated with early rapid kidney function decline in type 2 diabetes.
PubMed ID 35363857(Europe PMC)
doi 10.1210/clinem/dgac192
Publication Date April 1, 2022
Journal J Clin Endocrinol Metab
Author(s) Gurung RL, M Y, Liu JJ, Dorajoo R, Wang J, Wang L, Liu S, Chan C, Ang K, Shao YM, Subramaniam T, Tang WE, Sum CF, Liu JJ, Lim SC.
Released in PGS Catalog: May 18, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002290
(GRS10_PUA)
 PGP000318 |
Gurung RL et al. J Clin Endocrinol Metab (2022)
 Uric acid level uric acid measurement 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002290/ScoringFiles/PGS002290.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013007 PGS002290
(GRS10_PUA)
 PSS009644|
East Asian Ancestry|
1,146 individuals
 PGP000318 |
Gurung RL et al. J Clin Endocrinol Metab (2022)
 Reported Trait: Plasma uric acid level β: 0.142 (0.025) — — Age, sex —
PPM013008 PGS002290
(GRS10_PUA)
 PSS009644|
East Asian Ancestry|
1,146 individuals
 PGP000318 |
Gurung RL et al. J Clin Endocrinol Metab (2022)
 Reported Trait: Rapid decline in kidney function OR: 1.12 [1.01, 1.24] — — Age, sex, MI, HbA1c, diabetes duration, SBP, eGFR, ln uACR, RAS antagonist and Insulin usage (yes/no) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009644 — —
[
  • 160 cases
  • , 986 controls
]
 — East Asian
(Chinese)		 — DN, SMART2D —