PGS Publication: PGP000320

Publication Information (EuropePMC)
Title A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening.
PubMed ID 35414057(Europe PMC)
doi 10.1038/s41467-022-29570-4
Publication Date April 12, 2022
Journal Nat Commun
Author(s) He YQ, Wang TM, Ji M, Mai ZM, Tang M, Wang R, Zhou Y, Zheng Y, Xiao R, Yang D, Wu Z, Deng C, Zhang J, Xue W, Dong S, Zhan J, Cai Y, Li F, Wu B, Liao Y, Zhou T, Zheng M, Jia Y, Li D, Cao L, Yuan L, Zhang W, Luo L, Tong X, Wu Y, Li X, Zhang P, Zheng X, Zhang S, Hu Y, Qin W, Deng B, Liang X, Fan P, Feng Y, Song J, Xie SH, Chang ET, Zhang Z, Huang G, Xu M, Feng L, Jin G, Bei J, Cao S, Liu Q, Kozlakidis Z, Mai H, Sun Y, Ma J, Hu Z, Liu J, Lung ML, Adami HO, Shen H, Ye W, Lam TH, Zeng YX, Jia WH.
Released in PGS Catalog: May 18, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002291
(PRS12_NPC)
 PGP000320 |
He YQ et al. Nat Commun (2022)
 Nasopharyngeal carcinoma nasopharyngeal neoplasm 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002291/ScoringFiles/PGS002291.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013010 PGS002291
(PRS12_NPC)
 PSS009646|
East Asian Ancestry|
2,893 individuals
 PGP000320 |
He YQ et al. Nat Commun (2022)
 Reported Trait: Nasopharyngeal carcinoma — AUROC: 0.64 — — —
PPM013011 PGS002291
(PRS12_NPC)
 PSS009646|
East Asian Ancestry|
2,893 individuals
 PGP000320 |
He YQ et al. Nat Commun (2022)
 Reported Trait: Nasopharyngeal carcinoma — AUROC: 0.69 — Family history of NPC —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009646 — —
[
  • 1,304 cases
  • , 1,589 controls
]
 — East Asian — NR —