PGS Publication: PGP000325

Publication Information (EuropePMC)
Title Prognostic significance of circulating insulin growth-like factor 1 and insulin growth-like factor binding protein 3 in renal cell carcinoma patients.
PubMed ID 35261807(Europe PMC)
doi
Publication Date Feb. 15, 2022
Journal American Journal of Cancer Research
Author(s) Tsai CW, Chang WS, Xu Y, Huang M, Tamboli P, Wood CG, Bau DT, Gu J.
Released in PGS Catalog: May 18, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002295
(GRS413_IGF-1)
 PGP000325 |
Tsai CW et al. American Journal of Cancer Research (2022)
 Insulin growth-like factor-1 level insulin like growth factor measurement 413
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002295/ScoringFiles/PGS002295.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013023 PGS002295
(GRS413_IGF-1)
 PSS009653|
European Ancestry|
1,010 individuals
 PGP000325 |
Tsai CW et al. American Journal of Cancer Research (2022)
 Reported Trait: Recurrence in renal cell carcinoma HR: 0.63 [0.42, 0.93] — Hazard Ratio (HR, above vs. below median): 0.63 [0.42, 0.93]
Odds Ratio (OR, above vs. below 75th percentile GRS): 0.73 [0.55, 0.96]		 Age, gender, smoking status, BMI, histology, stage, grade, and treatment —
PPM013024 PGS002295
(GRS413_IGF-1)
 PSS009653|
European Ancestry|
1,010 individuals
 PGP000325 |
Tsai CW et al. American Journal of Cancer Research (2022)
 Reported Trait: Survival in renal cell carcinoma HR: 0.65 [0.44, 0.95] — Hazard Ratio (HR, above vs. below median): 0.65 [0.44, 0.95]
Odds Ratio (OR, above vs. below 75th percentile GRS): 0.66 [0.5, 0.87]		 Age, gender, smoking status, BMI, histology, stage, grade, and treatment —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009653 — — 1,010 individuals — European — NR —