PGS Publication: PGP000334

Publication Information (EuropePMC)
Title Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
PubMed ID 35253861(Europe PMC)
doi 10.1093/brain/awac092
Publication Date March 7, 2022
Journal Brain
Author(s) Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N, University of California San Francisco MS-EPIC Team, Schaefer C, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR.
Released in PGS Catalog: June 29, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002726
(PGS_MS_Brain)
 PGP000334 |
Shams H et al. Brain (2022)
 Multiple sclerosis multiple sclerosis 476,399
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002726/ScoringFiles/PGS002726.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014749 PGS002726
(PGS_MS_Brain)
 PSS009883|
European Ancestry|
253,419 individuals
 PGP000334 |
Shams H et al. Brain (2022)
 Reported Trait: Multiple sclerosis — AUROC: 0.73 [0.72, 0.74] Odds ratio (OR, top 10% vs median): 5.3 [4.7, 6.0] — —
PPM014750 PGS002726
(PGS_MS_Brain)
 PSS009882|
European Ancestry|
938 individuals
 PGP000334 |
Shams H et al. Brain (2022)
 Reported Trait: Multiple sclerosis — AUROC: 0.8 [0.76, 0.82] Odds ratio (OR, top 10% vs median): 15.0 [10.4, 24.0] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009882 — —
[
  • 433 cases
  • , 505 controls
]
 — European — KP —
PSS009883 — —
[
  • 1,354 cases
  • , 252,065 controls
]
 — European — UKB —