PGS Publication: PGP000338

Publication Information (EuropePMC)
Title Utility of Diabetes Type-Specific Genetic Risk Scores for the Classification of Diabetes Type Among Multiethnic Youth.
PubMed ID 35312757(Europe PMC)
doi 10.2337/dc20-2872
Publication Date May 1, 2022
Journal Diabetes Care
Author(s) Oram RA, Sharp SA, Pihoker C, Ferrat L, Imperatore G, Williams A, Redondo MJ, Wagenknecht L, Dolan LM, Lawrence JM, Weedon MN, D'Agostino R, Hagopian WA, Divers J, Dabelea D.
Released in PGS Catalog: June 29, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000024
(GRS2)
 PGP000014 |
Sharp SA et al. Diabetes Care (2019)
 Type 1 diabetes (T1D) type 1 diabetes mellitus 85
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000024/ScoringFiles/PGS000024.txt.gz
PGS000036
(gePS_T2D)
 PGP000023 |
Mahajan A et al. Nat Genet (2018)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 171,249
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000036/ScoringFiles/PGS000036.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014802 PGS000036
(gePS_T2D)
 PSS009895|
European Ancestry|
1,168 individuals
 PGP000338 |
Oram RA et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Diabetes autoantibody positive insulin sensitive — AUROC: 0.661 [0.606, 0.716] — — —
PPM014801 PGS000024
(GRS2)
 PSS009895|
European Ancestry|
1,168 individuals
 PGP000338 |
Oram RA et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Diabetes autoantibody positive insulin sensitive — AUROC: 0.864 [0.823, 0.905] — — —
PPM014803 PGS000024
(GRS2)
 PSS009893|
African Ancestry|
366 individuals
 PGP000338 |
Oram RA et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Diabetes autoantibody positive insulin sensitive — AUROC: 0.851 [0.805, 0.897] — — —
PPM014804 PGS000036
(gePS_T2D)
 PSS009893|
African Ancestry|
366 individuals
 PGP000338 |
Oram RA et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Diabetes autoantibody positive insulin sensitive — AUROC: 0.574 [0.506, 0.643] — — —
PPM014805 PGS000024
(GRS2)
 PSS009894|
Hispanic or Latin American Ancestry|
412 individuals
 PGP000338 |
Oram RA et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Diabetes autoantibody positive insulin sensitive — AUROC: 0.935 [0.906, 0.964] — — —
PPM014806 PGS000036
(gePS_T2D)
 PSS009894|
Hispanic or Latin American Ancestry|
412 individuals
 PGP000338 |
Oram RA et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Diabetes autoantibody positive insulin sensitive — AUROC: 0.722 [0.667, 0.778] — — —
PPM014807 PGS000024
(GRS2)
 PSS009896|
Ancestry Not Reported|
99 individuals
 PGP000338 |
Oram RA et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Diabetes autoantibody positive insulin sensitive — AUROC: 0.79 [0.679, 0.902] — — —
PPM014808 PGS000036
(gePS_T2D)
 PSS009896|
Ancestry Not Reported|
99 individuals
 PGP000338 |
Oram RA et al. Diabetes Care (2022)
|Ext.		 Reported Trait: Diabetes autoantibody positive insulin sensitive — AUROC: 0.677 [0.532, 0.822] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009893 — — 366 individuals — African American or Afro-Caribbean — SEARCH —
PSS009894 — — 412 individuals — Hispanic or Latin American — SEARCH —
PSS009895 — — 1,168 individuals — European — SEARCH —
PSS009896 — — 99 individuals — Not reported — SEARCH —