PGS Publication: PGP000345

Publication Information (EuropePMC)
Title Evaluating risk for alcohol use disorder: Polygenic risk scores and family history.
PubMed ID 35267208(Europe PMC)
doi 10.1111/acer.14772
Publication Date March 10, 2022
Journal Alcohol Clin Exp Res
Author(s) Lai D, Johnson EC, Colbert S, Pandey G, Chan G, Bauer L, Francis MW, Hesselbrock V, Kamarajan C, Kramer J, Kuang W, Kuo S, Kuperman S, Liu Y, McCutcheon V, Pang Z, Plawecki MH, Schuckit M, Tischfield J, Wetherill L, Zang Y, Edenberg HJ, Porjesz B, Agrawal A, Foroud T.
Released in PGS Catalog: Aug. 3, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002738
(PRS_AUD)
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Alcohol use disorder alcohol dependence 326,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002738/ScoringFiles/PGS002738.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014841 PGS002738
(PRS_AUD)
 PSS009911|
European Ancestry|
7,900 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder β: 3.17 (1.87) — Odds Ratio (OR top 10% vs rest): 1.96 [1.54, 2.51] — —
PPM014839 PGS002738
(PRS_AUD)
 PSS009910|
European Ancestry|
2,722 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder (AUD) in individuals with unknown family history of AUD β: 2.91 (0.38) — Odds Ratio (OR top 10% vs rest): 1.5 [0.98, 2.29] — —
PPM014838 PGS002738
(PRS_AUD)
 PSS009909|
European Ancestry|
4,842 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder (AUD) in individuals with family history of AUD β: 2.43 (0.6) — Odds Ratio (OR top 10% vs rest): 1.86 [1.35, 2.56] — —
PPM014840 PGS002738
(PRS_AUD)
 PSS009908|
European Ancestry|
336 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder (AUD) in individuals without family history of AUD β: 2.64 (0.47) — Odds Ratio (OR top 10% vs rest): 0.45 [0.12, 1.69] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009909 — —
[
  • 2,531 cases
  • , 669 controls
]
 — European — COGA —
PSS009910 — —
[
  • 850 cases
  • , 840 controls
]
 — European — COGA —
PSS009911 — —
[
  • 3,451 cases
  • , 1,616 controls
]
,
48.0 % Male samples
 — European — COGA —
PSS009908 — —
[
  • 72 cases
  • , 107 controls
]
 — European — COGA —