PGS Publication: PGP000350

Publication Information (EuropePMC)
Title Combined Performance of Fecal Immunochemical Tests and a Genetic Risk Score for Advanced Neoplasia Detection.
PubMed ID 35679356(Europe PMC)
doi 10.1158/1940-6207.capr-21-0552
Publication Date Aug. 1, 2022
Journal Cancer Prev Res (Phila)
Author(s) Niedermaier T, Guo F, Weigl K, Hoffmeister M, Brenner H.
Released in PGS Catalog: Aug. 3, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS002265
(PRS140_CRC)
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Colorectal cancercolorectal cancer140
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002265/ScoringFiles/PGS002265.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM014884PGS002265
(PRS140_CRC)
PSS009918|
European Ancestry|
5,306 individuals
PGP000350 |
Niedermaier T et al. Cancer Prev Res (Phila) (2022)
|Ext.		Reported Trait: Advanced colorectal neoplasia (Ridascreen model)OR: 1.025
β: 0.02451		AUROC: 0.524 [0.499, 0.55]———
PPM014885PGS002265
(PRS140_CRC)
PSS009918|
European Ancestry|
5,306 individuals
PGP000350 |
Niedermaier T et al. Cancer Prev Res (Phila) (2022)
|Ext.		Reported Trait: Advanced colorectal neoplasia (FOB Gold model)OR: 1.036
β: 0.03518		AUROC: 0.53 [0.516, 0.545]———
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS009918——5,306 individuals,
51.9 % Male samples
Mean = 62.1 yearsEuropean—BLITZ—
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