PGS Publication: PGP000353

Publication Information (EuropePMC)
Title Contribution of Genome-Wide Polygenic Score to Risk of Coronary Artery Disease in Childhood Cancer Survivors.
PubMed ID 35818558(Europe PMC)
doi 10.1016/j.jaccao.2022.04.003
Publication Date June 21, 2022
Journal JACC CardioOncol
Author(s) Sapkota Y, Liu Q, Li N, Bhatt NS, Ehrhardt MJ, Wilson CL, Wang Z, Jefferies JL, Zhang J, Armstrong GT, Hudson MM, Robison LL, Mulrooney DA, Yasui Y.
Released in PGS Catalog: Aug. 3, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disease 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014904 PGS000013
(GPS_CAD)
 PSS009922|
European Ancestry|
2,119 individuals
 PGP000353 |
Sapkota Y et al. JACC CardioOncol (2022)
|Ext.		 Reported Trait: Coronary artery disease in childhood cancer survivors HR: 1.25 [1.04, 1.49] — — — —
PPM014905 PGS000013
(GPS_CAD)
 PSS009922|
European Ancestry|
2,119 individuals
 PGP000353 |
Sapkota Y et al. JACC CardioOncol (2022)
|Ext.		 Reported Trait: Coronary artery disease in childhood cancer survivors aged <10 years at diagnosis and treated with >25 Gy — AUROC: 0.714 Hazard Ratio (HR, top vs. bottom tertile): 15.49 [5.24, 45.52] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009922 — —
[
  • 120 cases
  • , 1,999 controls
]
 — European — NR —