| Publication Information (EuropePMC) | |
| Title | Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke. |
| PubMed ID | 36240095(Europe PMC) |
| doi | 10.1212/wnl.0000000000201006 |
| Publication Date | Aug. 31, 2022 |
| Journal | Neurology |
| Author(s) | Jaworek T, Xu H, Gaynor BJ, Cole JW, Rannikmae K, Stanne TM, Tomppo L, Abedi V, Amouyel P, Armstrong ND, Attia J, Bell S, Benavente OR, Boncoraglio GB, Butterworth A, Cervical Artery Dissections and Ischemic Stroke Patients (CADSIP) Consortium, Carcel-Marquez J, Chen Z, Chong M, Cruchaga C, Cushman M, Danesh J, Debette S, Duggan DJ, Durda JP, Engstrom G, Enzinger C, Faul JD, Fecteau NS, Fernandez-Cadenas I, Gieger C, Giese AK, Grewal RP, Grittner U, Havulinna AS, Heitsch L, Hochberg MC, Holliday E, Hu J, Ilinca A, INVENT Consortium, Irvin MR, Jackson RD, Jacob MA, Janssen RR, Jimenez-Conde J, Johnson JA, Kamatani Y, Kardia SL, Koido M, Kubo M, Lange L, Lee JM, Lemmens R, Levi CR, Li J, Li L, Lin K, Lopez H, Luke S, Maguire J, McArdle PF, McDonough CW, Meschia JF, Metso T, Muller-Nurasyid M, O'Connor TD, O'Donnell M, Peddareddygari LR, Pera J, Perry JA, Peters A, Putaala J, Ray D, Rexrode K, Ribases M, Rosand J, Rothwell PM, Rundek T, Ryan KA, Sacco RL, Salomaa V, Sanchez-Mora C, Schmidt R, Sharma P, Slowik A, Smith JA, Smith NL, Wassertheil-Smoller S, Soederholm M, Stine OC, Strbian D, Sudlow CL, Tatlisumak T, Terao C, Thijs V, Torres-Aguila NP, Tregouet DA, Tuladhar AM, Veldink JH, Walters RG, Weir DR, Woo D, Worrall BB, Hong CC, Ross O, Zand R, Leeuw FE, Lindgren AG, Pare G, Anderson CD, Markus HS, Jern C, Malik R, Dichgans M, Mitchell BD, Kittner SJ, Early Onset Stroke Genetics Consortium of the International Stroke Genetics Consortium (ISGC). |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000043 (PRS_VTE) |
PGP000030 | Klarin D et al. Nat Genet (2019) |
Venous thromboembolism | venous thromboembolism | 297 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000043/ScoringFiles/PGS000043.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM014990 | PGS000043 (PRS_VTE) |
PSS009948| Multi-ancestry (including European)| 615,967 individuals |
PGP000369 | Jaworek T et al. Neurology (2022) |Ext. |
Reported Trait: Early onset stroke | OR: 1.13 [1.1, 1.16] | — | — | 10 principal components for ancestry and sex | — |
| PPM014991 | PGS000043 (PRS_VTE) |
PSS009948| Multi-ancestry (including European)| 615,967 individuals |
PGP000369 | Jaworek T et al. Neurology (2022) |Ext. |
Reported Trait: Late onset stroke | OR: 1.04 [1.01, 1.08] | — | — | 10 principal components for ancestry and sex | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009948 | — | — | [
|
— | African unspecified, European, Hispanic or Latin American, African American or Afro-Caribbean, Asian unspecified | Africa, European, Hispanics, Afro-Carribean, Pan-Asian | BBJ, EPIC_CAD, GMC, RACE, UKB | HELSINKI |