PGS Publication: PGP000374

Publication Information (EuropePMC)
Title Self-reported walking pace, polygenic risk scores and risk of coronary artery disease in UK biobank.
PubMed ID 36163213(Europe PMC)
doi 10.1016/j.numecd.2022.08.021
Publication Date Sept. 2, 2022
Journal Nutr Metab Cardiovasc Dis
Author(s) Zaccardi F, Timmins IR, Goldney J, Dudbridge F, Dempsey PC, Davies MJ, Khunti K, Yates T.
Released in PGS Catalog: Oct. 19, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disease 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015491 PGS000013
(GPS_CAD)
 PSS009960|
Ancestry Not Reported|
172,066 individuals
 PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.		 Reported Trait: 10-year risk of coronary artery disease for slow walkers — — Hazard Ratio (HR, top 20% vs. bottom 80%): 9.6 [8.62, 10.57] — —
PPM015493 PGS000013
(GPS_CAD)
 PSS009960|
Ancestry Not Reported|
172,066 individuals
 PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.		 Reported Trait: Difference in 10-year risk of coronary artery disease between slow walkers and brisk walkers — — Hazard Ratio (HR, top 20% vs. bottom 80%): 3.63 [2.58, 4.67] — —
PPM015490 PGS000013
(GPS_CAD)
 PSS009961|
Ancestry Not Reported|
208,627 individuals
 PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.		 Reported Trait: 10-year risk of coronary artery disease for slow walkers — — Hazard Ratio (HR, top 20% vs. bottom 80%): 2.72 [2.3, 3.13] — —
PPM015492 PGS000013
(GPS_CAD)
 PSS009961|
Ancestry Not Reported|
208,627 individuals
 PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.		 Reported Trait: Difference in 10-year risk of coronary artery disease between slow walkers and brisk walkers — — Hazard Ratio (HR, top 20% vs. bottom 80%): 1.26 [0.81, 1.71] — —
PPM015494 PGS000013
(GPS_CAD)
 PSS009961|
Ancestry Not Reported|
208,627 individuals
 PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.		 Reported Trait: 10-year risk of coronary artery disease — C-index: 0.801 [0.793, 0.808] — Age (continuous), Townsend deprivation index (continuous), systolic blood pressure (continuous), LDL cholesterol (continuous), smoking status (current/former/never), history of diabetes (yes/no), family history of myocardial infarction (yes/no), walking pace —
PPM015495 PGS000013
(GPS_CAD)
 PSS009960|
Ancestry Not Reported|
172,066 individuals
 PGP000374 |
Zaccardi F et al. Nutr Metab Cardiovasc Dis (2022)
|Ext.		 Reported Trait: 10-year risk of coronary artery disease — C-index: 0.732 [0.728, 0.737] — Age (continuous), Townsend deprivation index (continuous), systolic blood pressure (continuous), LDL cholesterol (continuous), smoking status (current/former/never), history of diabetes (yes/no), family history of myocardial infarction (yes/no), walking pace —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009960 — — 172,066 individuals,
100.0 % Male samples
 Mean = 57.8 years Not reported — UKB —
PSS009961 — — 208,627 individuals,
0.0 % Male samples
 Mean = 57.4 years Not reported — UKB —