PGS Publication: PGP000375

Publication Information (EuropePMC)
Title Genetic risk and incident venous thromboembolism in middle-aged and older adults following COVID-19 vaccination.
PubMed ID 36111372(Europe PMC)
doi 10.1111/jth.15879
Publication Date Sept. 15, 2022
Journal J Thromb Haemost
Author(s) Xie J, Prats-Uribe A, Gordillo-Marañón M, Strauss VY, Gill D, Prieto-Alhambra D.
Released in PGS Catalog: Oct. 19, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002794
(PRS_VTE)
 PGP000375 |
Xie J et al. J Thromb Haemost (2022)
 Venous thromboembolism venous thromboembolism 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002794/ScoringFiles/PGS002794.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015496 PGS002794
(PRS_VTE)
 PSS009962|
Ancestry Not Reported|
359,310 individuals
 PGP000375 |
Xie J et al. J Thromb Haemost (2022)
 Reported Trait: Incident venous thromboembolism witihin 28 days after first dose of COVID-19 vaccination HR: 1.38 [1.13, 1.7] — — Age (at the index date), sex, and genetic ancestry (quantified by the first ten principal components —
PPM015497 PGS002794
(PRS_VTE)
 PSS009962|
Ancestry Not Reported|
359,310 individuals
 PGP000375 |
Xie J et al. J Thromb Haemost (2022)
 Reported Trait: Incident venous thromboembolism witihin 90 days after first dose of COVID-19 vaccination HR: 1.34 [1.2, 1.5] — — Age (at the index date), sex, and genetic ancestry (quantified by the first ten principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009962 — — 359,310 individuals,
44.6 % Male samples
 Mean = 69.05 years
Sd = 8.04 years		 Not reported — UKB —