PGS Publication: PGP000387

Publication Information (EuropePMC)
Title Association of the interaction between mosaic chromosomal alterations and polygenic risk score with the risk of lung cancer: an array-based case-control association and prospective cohort study.
PubMed ID 36265503(Europe PMC)
doi 10.1016/s1470-2045(22)00600-3
Publication Date Oct. 17, 2022
Journal Lancet Oncol
Author(s) Qin N, Wang C, Chen C, Yang L, Liu S, Xiang J, Xie Y, Liang S, Zhou J, Xu X, Zhao X, Zhu M, Jin G, Ma H, Dai J, Hu Z, Shen H.
Released in PGS Catalog: Nov. 7, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002808
(PGS20_LC)
 PGP000387 |
Qin N et al. Lancet Oncol (2022)
 Lung cancer lung carcinoma 20
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002808/ScoringFiles/PGS002808.txt.gz

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000070
(PRS_LC_C)
 PGP000049 |
Dai J et al. Lancet Respir Med (2019)
 Lung cancer lung adenocarcinoma 19
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000070/ScoringFiles/PGS000070.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015573 PGS000070
(PRS_LC_C)
 PSS009987|
East Asian Ancestry|
19,546 individuals
 PGP000387 |
Qin N et al. Lancet Oncol (2022)
|Ext.		 Reported Trait: Lung cancer — — Odds ratio (OR, high vs low risk): 2.18 [2.00, 2.38] — —
PPM015574 PGS002808
(PGS20_LC)
 PSS009988|
European Ancestry|
450,821 individuals
 PGP000387 |
Qin N et al. Lancet Oncol (2022)
 Reported Trait: Lung cancer — — Hazard ratio (HR, high vs low risk): 1.48 [1.31, 1.68] — —
PPM015575 PGS000070
(PRS_LC_C)
 PSS009987|
East Asian Ancestry|
19,546 individuals
 PGP000387 |
Qin N et al. Lancet Oncol (2022)
|Ext.		 Reported Trait: Lung cancer x autosomal mosaic loss abnormalities interaction OR: 2.36 [1.09, 5.08] — — — —
PPM015576 PGS002808
(PGS20_LC)
 PSS009988|
European Ancestry|
450,821 individuals
 PGP000387 |
Qin N et al. Lancet Oncol (2022)
 Reported Trait: Lung cancer x autosomal mosaic loss abnormalities interaction HR: 1.95 [1.02, 3.7] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009987 — —
[
  • 10,248 cases
  • , 9,298 controls
]
,
63.0 % Male samples
 — East Asian
(Chinese)		 — NR NJLCC
PSS009988 — —
[
  • 2,088 cases
  • , 448,733 controls
]
,
46.0 % Male samples
 — European — UKB —