PGS Publication: PGP000388

Publication Information (EuropePMC)
Title Reclassification of coronary artery disease risk using genetic risk score among subjects with borderline or intermediate clinical risk.
PubMed ID 36275420(Europe PMC)
doi 10.1016/j.ijcha.2022.101136
Publication Date Oct. 13, 2022
Journal Int J Cardiol Heart Vasc
Author(s) Ahmed R, Shi Z, Rifkin AS, Wei J, Lilly Zheng S, Helfand BT, Hulick PJ, Qamar A, Davidson DJ, Billings LK, Xu J.
Released in PGS Catalog: Nov. 7, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002809
(GRS_CAD)
 PGP000388 |
Ahmed R et al. Int J Cardiol Heart Vasc (2022)
 Coronary artery disease coronary artery disease 205
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002809/ScoringFiles/PGS002809.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015577 PGS002809
(GRS_CAD)
 PSS009989|
European Ancestry|
360,098 individuals
 PGP000388 |
Ahmed R et al. Int J Cardiol Heart Vasc (2022)
 Reported Trait: Incident coronary artery disease — — Hazard ratio (HR, >=3 vs <0.5 risk): 3.02 [2.73, 3.33] — Calculated as Population‐standardized GRS
PPM015578 PGS002809
(GRS_CAD)
 PSS009989|
European Ancestry|
360,098 individuals
 PGP000388 |
Ahmed R et al. Int J Cardiol Heart Vasc (2022)
 Reported Trait: Incident coronary artery disease in subjects with borderline-/intermediate-ASCVD risk — — Hazard ratio (HR, >=3 vs <0.5 risk): 2.91 [2.59, 3.26] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009989 — — 360,098 individuals,
45.1 % Male samples
 Mean = 56.95 years European — UKB —