PGS Publication: PGP000428

Publication Information (EuropePMC)
Title CanRisk-Prostate: A Comprehensive, Externally Validated Risk Model for the Prediction of Future Prostate Cancer.
PubMed ID 36493335(Europe PMC)
doi 10.1200/jco.22.01453
Publication Date Dec. 9, 2022
Journal J Clin Oncol
Author(s) Nyberg T, Brook MN, Ficorella L, Lee A, Dennis J, Yang X, Wilcox N, Dadaev T, Govindasami K, Lush M, Leslie G, Lophatananon A, Muir K, Bancroft E, Easton DF, Tischkowitz M, Kote-Jarai Z, Eeles R, Antoniou AC.
Released in PGS Catalog: Feb. 8, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003415
(PGS268_PCa)
 PGP000428 |
Nyberg T et al. J Clin Oncol (2022)
 Prostate cancer prostate carcinoma 268
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003415/ScoringFiles/PGS003415.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017067 PGS003415
(PGS268_PCa)
 PSS010112|
European Ancestry|
170,850 individuals
 PGP000428 |
Nyberg T et al. J Clin Oncol (2022)
 Reported Trait: 5 years incident prostate cancer risk — C-index: 0.79 [0.783, 0.797] — — —
PPM017068 PGS003415
(PGS268_PCa)
 PSS010112|
European Ancestry|
170,850 individuals
 PGP000428 |
Nyberg T et al. J Clin Oncol (2022)
 Reported Trait: 10 years incident prostate cancer risk — C-index: 0.772 [0.768, 0.777] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010112 — — 170,850 individuals,
100.0 % Male samples
 — European — UKB —