PGS Publication: PGP000431

Publication Information (EuropePMC)
Title Genome-wide association study reveals ethnicity-specific SNPs associated with ankylosing spondylitis in the Taiwanese population.
PubMed ID 36510243(Europe PMC)
doi 10.1186/s12967-022-03701-3
Publication Date Dec. 12, 2022
Journal J Transl Med
Author(s) Ko CL, Lin WZ, Lee MT, Chang YT, Lin HC, Wu YS, Lin JF, Pan KT, Chang YC, Lee KH, Lee YL, Hsieh TT, Huang JH, Wang CH, Yang SS, Chen HC, Chu CM.
Released in PGS Catalog: Feb. 8, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003421
(PRS16_C+T)
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Ankylosing spondylitis ankylosing spondylitis 16
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003421/ScoringFiles/PGS003421.txt.gz
PGS003423
(PRS100_Lassosum)
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Ankylosing spondylitis ankylosing spondylitis 100
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003423/ScoringFiles/PGS003423.txt.gz
PGS003424
(PRS100_LDpred2)
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Ankylosing spondylitis ankylosing spondylitis 100
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003424/ScoringFiles/PGS003424.txt.gz
PGS003420
(PRS100_PRScs)
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Ankylosing spondylitis ankylosing spondylitis 100
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003420/ScoringFiles/PGS003420.txt.gz
PGS003422
(PRS16_PRSice2)
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Ankylosing spondylitis ankylosing spondylitis 16
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003422/ScoringFiles/PGS003422.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017073 PGS003420
(PRS100_PRScs)
 PSS010115|
East Asian Ancestry|
1,298 individuals
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Reported Trait: Ankylosing spondylitis — AUROC: 0.7886 — — —
PPM017074 PGS003421
(PRS16_C+T)
 PSS010115|
East Asian Ancestry|
1,298 individuals
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Reported Trait: Ankylosing spondylitis — AUROC: 0.7876 — — —
PPM017075 PGS003422
(PRS16_PRSice2)
 PSS010115|
East Asian Ancestry|
1,298 individuals
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Reported Trait: Ankylosing spondylitis — AUROC: 0.7876 — — —
PPM017076 PGS003423
(PRS100_Lassosum)
 PSS010115|
East Asian Ancestry|
1,298 individuals
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Reported Trait: Ankylosing spondylitis — AUROC: 0.7754 — — —
PPM017077 PGS003424
(PRS100_LDpred2)
 PSS010115|
East Asian Ancestry|
1,298 individuals
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Reported Trait: Ankylosing spondylitis — AUROC: 0.7605 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010115 — —
[
  • 185 cases
  • , 1,112 controls
]
 — East Asian
(Taiwanese)		 — NR TPMI