PGS Publication: PGP000434

Publication Information (EuropePMC)
Title Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass.
PubMed ID 36944631(Europe PMC)
doi 10.1038/s41467-023-37173-w
Publication Date March 21, 2023
Journal Nat Commun
Author(s) Khurshid S, Lazarte J, Pirruccello JP, Weng LC, Choi SH, Hall AW, Wang X, Friedman SF, Nauffal V, Bi... ddinger KJ, Aragam KG, Batra P, Ho JE, Philippakis AA, Ellinor PT, Lubitz SA.Show more
Released in PGS Catalog: March 24, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS003427
(lvmi)
PGP000434 |
Khurshid S et al. Nat Commun (2023)
Left ventricular mass index (LVMI)left ventricular mass index465
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003427/ScoringFiles/PGS003427.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM017100PGS003427
(lvmi)
PSS010123|
Multi-ancestry (including European)|
443,326 individuals
PGP000434 |
Khurshid S et al. Nat Commun (2023)
Reported Trait: incident implantable cardioverter-defibrillator implantHR: 1.07——age, sex, PC 1-5—
PPM017101PGS003427
(lvmi)
PSS010124|
Multi-ancestry (including European)|
29,354 individuals
PGP000434 |
Khurshid S et al. Nat Commun (2023)
Reported Trait: incident implantable cardioverter-defibrillator implantHR: 1.05——age, sex, PC 1-5—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS010123—443,326 individuals,
45.5 % Male samples
Mean = 57.2 yearsEuropean, NR94% EuropeanUKB—
PSS010124—29,354 individuals,
45.5 % Male samples
Mean = 55.4 yearsEuropean, NR85% EuropeanPHB—
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