PGS Publication: PGP000440

Publication Information (EuropePMC)
Title Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.
PubMed ID 36576811(Europe PMC)
doi 10.1001/jamacardio.2022.4466
Publication Date Feb. 1, 2023
Journal JAMA Cardiol
Author(s) Marston NA, Pirruccello JP, Melloni GEM, Koyama S, Kamanu FK, Weng LC, Roselli C, Kamatani Y, Komuro I, Aragam KG, Butterworth AS, Ito K, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT.
Released in PGS Catalog: March 3, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003438
(PRS241_CAD)
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Coronary artery disease coronary artery disease 241
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003438/ScoringFiles/PGS003438.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017150 PGS003438
(PRS241_CAD)
 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Myocardial infarction HR: 1.07 [1.06, 1.08] — — — —
PPM017151 PGS003438
(PRS241_CAD)
 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Myocardial infarction in >60 years HR: 1.42 [1.37, 1.48] — — — —
PPM017152 PGS003438
(PRS241_CAD)
 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Myocardial infarction in aged 50-60 years HR: 1.46 [1.38, 1.53] — — — —
PPM017153 PGS003438
(PRS241_CAD)
 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Myocardial infarction in < 50 years HR: 1.72 [1.56, 1.89] — — — —
PPM017154 PGS003438
(PRS241_CAD)
 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Atherosclerotic Cardiovascular Disease (ASCVD) events — C-index: 0.74 [0.73, 0.74] — — —
PPM017155 PGS003438
(PRS241_CAD)
 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Atherosclerotic Cardiovascular Disease (ASCVD) events in >60 years — C-index: 0.68 [0.67, 0.69] — — —
PPM017156 PGS003438
(PRS241_CAD)
 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Atherosclerotic Cardiovascular Disease (ASCVD) events in aged 50-60 years — C-index: 0.71 [0.7, 0.73] — — —
PPM017157 PGS003438
(PRS241_CAD)
 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Atherosclerotic Cardiovascular Disease (ASCVD) events in < 50 years — C-index: 0.76 [0.73, 0.78] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010137 Incident MI was defined by the general International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10), code I21 and its subcodes I210-I214 and I219. — 330,201 individuals,
43.0 % Male samples
 Median = 57.0 years European — UKB —