PGS Publication: PGP000444

Publication Information (EuropePMC)
Title Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer's disease and/or major depressive disorder.
PubMed ID 36653486(Europe PMC)
doi 10.1038/s41598-023-28057-6
Publication Date Jan. 18, 2023
Journal Sci Rep
Author(s) Petrican R, Paine AL, Escott-Price V, Shelton KH.
Released in PGS Catalog: March 3, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
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Multi-ancestry (excluding European)
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South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003440
(GRS11_nonapoeAD)
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Alzheimer's disease in non APOE APOE carrier status,
Alzheimer disease		 11
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003440/ScoringFiles/PGS003440.txt.gz
PGS003441
(GRS28_AD)
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Alzheimer's disease Alzheimer disease 28
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003441/ScoringFiles/PGS003441.txt.gz
PGS003442
(GRS8_MD)
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Major depressive disorder major depressive disorder 8
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003442/ScoringFiles/PGS003442.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017176 PGS003440
(GRS11_nonapoeAD)
 PSS010155|
Ancestry Not Reported|
117 individuals
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Reported Trait: Fluid cognition via cortical thickness in adoptees β: 0.008 (0.005) — — — —
PPM017177 PGS003440
(GRS11_nonapoeAD)
 PSS010156|
Ancestry Not Reported|
4,382 individuals
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Reported Trait: Fluid cognition via cortical thickness in non-adoptees β: 0.0001 (0.001) — — — —
PPM017178 PGS003441
(GRS28_AD)
 PSS010155|
Ancestry Not Reported|
117 individuals
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Reported Trait: Fluid cognition via cortical thickness in adoptees β: 0.011 (0.006) — — — —
PPM017179 PGS003441
(GRS28_AD)
 PSS010156|
Ancestry Not Reported|
4,382 individuals
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Reported Trait: Fluid cognition via cortical thickness in non-adoptees β: -0.001 (0.001) — — — —
PPM017180 PGS003442
(GRS8_MD)
 PSS010155|
Ancestry Not Reported|
117 individuals
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Reported Trait: Fluid cognition via average SST BOLD activation in adoptees β: 0.064 (0.027) — — — —
PPM017181 PGS003442
(GRS8_MD)
 PSS010156|
Ancestry Not Reported|
4,382 individuals
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Reported Trait: Fluid cognition via verage SST BOLD activation in non-adoptees β: 0.0 (0.004) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010155 — — 117 individuals,
50.0 % Male samples
 Mean = 9.96 years Not reported — NR ABCD
PSS010156 — — 4,382 individuals,
50.0 % Male samples
 Mean = 9.94 years Not reported — NR ABCD