PGS Publication: PGP000459

Publication Information (EuropePMC)
Title Genetic risk scores and dementia risk across different ethnic groups in UK Biobank.
PubMed ID 36477264(Europe PMC)
doi 10.1371/journal.pone.0277378
Publication Date Dec. 7, 2022
Journal PLoS One
Author(s) Mukadam N, Giannakopoulou O, Bass N, Kuchenbaecker K, McQuillin A.
Released in PGS Catalog: April 12, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003574
(GRS_Dementia21)
 PGP000459 |
Mukadam N et al. PLoS One (2022)
 Alzheimer's disease (late onset) Alzheimer disease 21
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003574/ScoringFiles/PGS003574.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018176 PGS003574
(GRS_Dementia21)
 PSS010944|
Multi-ancestry (including European)|
378,471 individuals
 PGP000459 |
Mukadam N et al. PLoS One (2022)
 Reported Trait: Dementia OR: 1.21 [1.18, 1.24] — — age, sex, ethnic group, PRS*ethnicity Excluding APOE variants
PPM018175 PGS003574
(GRS_Dementia21)
 PSS010944|
Multi-ancestry (including European)|
378,471 individuals
 PGP000459 |
Mukadam N et al. PLoS One (2022)
 Reported Trait: Dementia OR: 1.73 [1.69, 1.77] — — age, sex, ethnic group, PRS*ethnicity —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010944 ICD10 codes, including F00, F01, F02, F03 and G30 subcategories. —
[
  • 4,729 cases
  • , 360,150 controls
]
,
46.2 % Male samples
 Mean = 56.8 years European
(white British)		 — UKB —
PSS010944 ICD10 codes, including F00, F01, F02, F03 and G30 subcategories. —
[
  • 73 cases
  • , 6,592 controls
]
,
54.2 % Male samples
 Mean = 53.4 years South Asian — UKB —
PSS010944 ICD10 codes, including F00, F01, F02, F03 and G30 subcategories. —
[
  • 87 cases
  • , 6,840 controls
]
,
43.6 % Male samples
 Mean = 51.9 years African unspecified
(Black)		 — UKB —